PMID- 26884418
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1741-7899 (Electronic)
IS  - 1470-1626 (Linking)
VI  - 151
IP  - 5
DP  - 2016 May
TI  - The role of anti-phospholipid antibodies in autoimmune reproductive failure.
PG  - R79-90
LID - 10.1530/REP-15-0545 [doi]
AB  - Anti-phospholipid antibodies (aPL) are autoantibodies that are associated with 
      thrombosis and a range of pregnancy complications including recurrent pregnancy 
      loss and pre-eclampsia. The three clinically relevant, well-characterized aPL are 
      anti-cardiolipin antibodies, lupus anticoagulant and anti-beta-2-glycoprotein I 
      (beta2GPI) antibodies. aPL do not bind directly to phospholipids but instead bind to 
      a plasma-binding 'cofactor'. The most extensively studied cofactor is beta2GPI, 
      whose role in pregnancy is not fully elucidated. Although the pathogenicity of 
      aPL in recurrent pregnancy loss is well established in humans and animal models, 
      the association of aPL with infertility does not appear to be causative. aPL may 
      exert their detrimental effects during pregnancy by directly binding trophoblast 
      cells of the placenta, altering trophoblast signalling, proliferation, invasion 
      and secretion of hormones and cytokines, and by increasing apoptosis. Heparin is 
      commonly used to treat pregnant women with aPL; however, as thrombotic events do 
      not occur in the placentae of all women with aPL, it may exert a protective 
      effect by preventing the binding of aPL to beta2GPI or by acting through 
      non-thrombotic pathways. The aim of this review is to present evidence 
      summarizing the current understanding of this field.
CI  - (c) 2016 Society for Reproduction and Fertility.
FAU - Pantham, Priyadarshini
AU  - Pantham P
AD  - Section of NeonatologyDepartment of Pediatrics, University of Colorado Anschutz 
      Medical Campus, Aurora, Colorado, USA priyadarshini.pantham@ucdenver.edu.
FAU - Abrahams, Vikki M
AU  - Abrahams VM
AD  - Department of Obstetrics, Gynecology and Reproductive SciencesYale School of 
      Medicine, New Haven, Connecticut, USA.
FAU - Chamley, Lawrence W
AU  - Chamley LW
AD  - Department of Obstetrics and GynaecologyUniversity of Auckland, Auckland, New 
      Zealand.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160216
PL  - England
TA  - Reproduction
JT  - Reproduction (Cambridge, England)
JID - 100966036
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Animals
MH  - Antibodies, Antiphospholipid/*immunology
MH  - Autoantibodies/*immunology
MH  - Autoimmune Diseases/*complications/immunology
MH  - Female
MH  - Humans
MH  - Infertility, Female/*etiology
MH  - Pregnancy
MH  - Reproduction/*immunology
EDAT- 2016/02/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/18 06:00
PHST- 2015/11/17 00:00 [received]
PHST- 2016/02/16 00:00 [accepted]
PHST- 2016/02/18 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - REP-15-0545 [pii]
AID - 10.1530/REP-15-0545 [doi]
PST - ppublish
SO  - Reproduction. 2016 May;151(5):R79-90. doi: 10.1530/REP-15-0545. Epub 2016 Feb 16.