PMID- 26885166
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160217
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 11
DP  - 2015
TI  - Effects of brain-derived neurotrophic factor-pretreated neuron stem cell 
      transplantation on Alzheimer's disease model mice.
PG  - 21947-55
AB  - Alzheimer's disease (AD) is a common case of dementia and its possible therapies, 
      such as neuron stem cell (NSC) transplantation therapy, have been studied for 
      years. In order to improve NSC transplantation effects, we were inspired to 
      pretreat NSC using brain-derived neurotrophic factor (BDNF) before 
      transplantation. The AD mouse model was constructed and effects of BDNF+NSC 
      transplant group and traditional NSC transplant group were compared using the 
      four indicators: conditions of learning and memory ability recovery tested by 
      Morris Water Maze (MWM), number of basal forebrain cholinergic neurons, 
      expression of synaptophysin, and number of acetylcholinesterase (ACHE)-positive 
      fibers detected by chemical staining. Results showed all the four indicators were 
      significantly lower in the AD model group than the control group (P < 0.05). 
      Traditional NSC transplantation could improve these indicators to some extent but 
      still possessed significant differences from the control group (P < 0.05). 
      Especially, the BDNF+NSC transplant group showed significant improvements in the 
      four indicators when compared with the AD model group (P < 0.05). Taken these 
      data together, BDNF pretreatment improved the NSC transplantation effects, 
      showing advantages over the traditional NSC transplantation. Our study could 
      facilitate the application of stem cell transplantation therapy to AD treatment.
FAU - Li, Tong
AU  - Li T
AD  - Department of Emergency, The First Affiliated Hospital, Zhejiang University 
      Hangzhou 310003, Zhejiang, China.
FAU - Yu, Ying
AU  - Yu Y
AD  - Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang 
      University Hangzhou 310003, Zhejiang, China.
FAU - Cai, Hongliu
AU  - Cai H
AD  - Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang 
      University Hangzhou 310003, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20151115
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4724012
OTO - NOTNLM
OT  - Alzheimer's disease (AD)
OT  - brain-derived neurotrophic factor (BDNF)
OT  - neuron stem cell (NSC)
OT  - transplantation
EDAT- 2016/02/18 06:00
MHDA- 2016/02/18 06:01
PMCR- 2015/11/15
CRDT- 2016/02/18 06:00
PHST- 2015/07/09 00:00 [received]
PHST- 2015/09/07 00:00 [accepted]
PHST- 2016/02/18 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/02/18 06:01 [medline]
PHST- 2015/11/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Nov 15;8(11):21947-55. eCollection 2015.