PMID- 26887371
OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR  - 20191210
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 54
IP  - 12
DP  - 2015 Dec
TI  - [Pulmonary hypertension in patients with chronic obstructive pulmonary disease: 
      clinical characteristics and risk factors].
PG  - 1037-40
AB  - OBJECTIVE: To investigate the clinical characteristics of pulmonary 
      hypertension(PH) in patients with chronic obstructive pulmonary disease(COPD) and 
      study the related risk factors. METHODS: Patients with stable COPD enrolled in 
      this study, undergoing examinations including full pulmonary function tests 
      (PFT), 6-minute walk distance (6MWD), Exercise Oxyhemoglobin, Saint. George's 
      respiratory questionnaire (SGRQ) and transthoracic echocardiography. Pulmonary 
      artery systolic pressure(sPAP) >/=36 mmHg (1 mmHg=0.133 kPa) was defined as PH. 
      RESULTS: A total of 251 patients were finally evaluable in this study. The 
      frequency of PH was 55.4% (139/251) in patients with stable COPD. Significant 
      differences were seen between patients with PH and without PH respectively in the 
      following factors (mean P<0.05): proportion of age >/= 60 years (69.8% vs 57.1%), 
      forced expiratory volume in one second (FEV(1)) (% predicted) [(47.5+/-8.2)% vs 
      (61.2+/-10.2)% and (49.8+/-7.9)% vs (66.4+/-11.3)%], sPAP [(41.9+/-9.1) mmHg vs 
      (28.2+/-3.2) mmHg], exercise oxyhemoglobin desaturation [(-5.5+/-3.2)% vs 
      (-2.2+/-1.2)%], 6MWD [(316.0+/-55.2)m vs (390.0+/-75.2)m]. The following variables were 
      negatively correlated with sPAP : 6MWD (r=-0.330, P=0.003), FEV(1)(% predicted) 
      (r=-0.210, P=0.024 and r=-0.130, P=0.012, respectively). The following variables 
      were positively correlated with sPAP: age (r= 0.560, P= 0.031), exercise 
      oxyhemoglobin desaturation> 3% (r= 0.540, P= 0.001). Logistic regression test has 
      showed that age >/= 60 years, exercise oxygen desaturation>3%, FEV(1) (% predicted) 
      <50%, 6MWD <350 m were risk factors for PH in COPD. CONCLUSION: The incidence of 
      PH in COPD increases with age, yet the performance of lung function and the 
      activity of endurance decrease in elder patients. Sixty years or older, exercise 
      oxygen desaturation> 3%, FEV(1) (% predicted) <50%, 6MWD <350 m are risk factors 
      of PH in COPD. Echocardiography or right heart catheterization when needed should 
      be considered to confirm the diagnosis.
FAU - Wang, Tongsheng
AU  - Wang T
AD  - Department of Respiratory Diseases, the First Affiliated Hospital of Henan 
      University of Science and Technology, Luoyang 471003, China.
FAU - Mao, Yimin
AU  - Mao Y
AD  - Department of Respiratory Diseases, the First Affiliated Hospital of Henan 
      University of Science and Technology, Luoyang 471003, China; Email: 
      yimin6107@sina.com.
FAU - Sun, Yuxia
AU  - Sun Y
AD  - Department of Respiratory Diseases, the First Affiliated Hospital of Henan 
      University of Science and Technology, Luoyang 471003, China.
FAU - Hou, Weiwei
AU  - Hou W
AD  - Department of Respiratory Diseases, the First Affiliated Hospital of Henan 
      University of Science and Technology, Luoyang 471003, China.
FAU - Feng, Yuxuan
AU  - Feng Y
AD  - Department of Respiratory Diseases, the First Affiliated Hospital of Henan 
      University of Science and Technology, Luoyang 471003, China.
FAU - Qu, Hongpei
AU  - Qu H
AD  - Department of Respiratory Diseases, the First Affiliated Hospital of Henan 
      University of Science and Technology, Luoyang 471003, China.
LA  - chi
PT  - Evaluation Study
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Age Factors
MH  - Echocardiography
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Hypertension, Pulmonary/*complications/physiopathology
MH  - Incidence
MH  - Male
MH  - Oxygen
MH  - Pulmonary Disease, Chronic Obstructive/*complications/physiopathology
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2016/02/19 06:00
MHDA- 2016/05/11 06:00
CRDT- 2016/02/19 06:00
PHST- 2016/02/19 06:00 [entrez]
PHST- 2016/02/19 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2015 Dec;54(12):1037-40.