PMID- 26887577
OWN - NLM
STAT- MEDLINE
DCOM- 20170823
LR  - 20181113
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 56
IP  - 3
DP  - 2017 Apr
TI  - Dietary antioxidant capacity and all-cause and cause-specific mortality in the 
      E3N/EPIC cohort study.
PG  - 1233-1243
LID - 10.1007/s00394-016-1172-6 [doi]
AB  - PURPOSE: The cellular oxidative stress (balance between pro-oxidant and 
      antioxidant) may be a major risk factor for chronic diseases. Antioxidant 
      capacity of human diet can be globally assessed through the dietary non-enzymatic 
      antioxidant capacity (NEAC). Our aim was to investigate the relationship between 
      the NEAC and all-cause and cause-specific mortality, and to test potential 
      interactions with smoking status, a well-known pro-oxidant factor. METHODS: Among 
      the French women of the E3N prospective cohort study initiated in 1990, including 
      4619 deaths among 1,199,011 persons-years of follow-up. A validated dietary 
      history questionnaire assessed usual food intake; NEAC intake was estimated using 
      a food composition table from two different methods: ferric ion reducing 
      antioxidant power (FRAP) and total radical-trapping antioxidant parameter (TRAP). 
      Hazard ratio (HR) estimates and 95 % confidence intervals (CI) were derived from 
      Cox proportional hazards regression models. RESULTS: In multivariate analyses, 
      FRAP dietary equivalent intake was inversely associated with mortality from 
      all-causes (HR for the fourth vs. the first quartile: HR(4) = 0.75, 95 % CI 0.67, 
      0.83, p (trend) < 0.0001), cancer, and cardiovascular diseases. Similar results 
      were obtained with TRAP. There was an interaction between NEAC dietary equivalent 
      intake and smoking status for all-cause and cardiovascular disease mortality, but 
      not cancer mortality (respectively, for FRAP, p (inter) = 0.002; 0.013; 0.113, 
      results were similar with TRAP), and the association was the strongest among 
      current smokers. CONCLUSION: This prospective cohort study highlights the 
      importance of antioxidant consumption for mortality prevention, especially among 
      current smokers.
FAU - Bastide, Nadia
AU  - Bastide N
AD  - CESP, Team 9, UMR-S 1018: INSERM, Gustave Roussy, Universite Paris-Sud, Espace 
      Maurice Tubiana, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
FAU - Dartois, Laureen
AU  - Dartois L
AD  - CESP, Team 9, UMR-S 1018: INSERM, Gustave Roussy, Universite Paris-Sud, Espace 
      Maurice Tubiana, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
FAU - Dyevre, Valerie
AU  - Dyevre V
AD  - CESP, Team 9, UMR-S 1018: INSERM, Gustave Roussy, Universite Paris-Sud, Espace 
      Maurice Tubiana, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
FAU - Dossus, Laure
AU  - Dossus L
AD  - CESP, Team 9, UMR-S 1018: INSERM, Gustave Roussy, Universite Paris-Sud, Espace 
      Maurice Tubiana, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
FAU - Fagherazzi, Guy
AU  - Fagherazzi G
AD  - CESP, Team 9, UMR-S 1018: INSERM, Gustave Roussy, Universite Paris-Sud, Espace 
      Maurice Tubiana, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
FAU - Serafini, Mauro
AU  - Serafini M
AD  - Functional Foods and Metabolic Stress Prevention Laboratory, Center of Nutrition, 
      Council for Agricultural Research and Economics, Center of Food and Nutrition, 
      Rome, Italy.
FAU - Boutron-Ruault, Marie-Christine
AU  - Boutron-Ruault MC
AD  - CESP, Team 9, UMR-S 1018: INSERM, Gustave Roussy, Universite Paris-Sud, Espace 
      Maurice Tubiana, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France. 
      Marie-christine.BOUTRON@gustaveroussy.fr.
LA  - eng
PT  - Journal Article
DEP - 20160218
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Antioxidants/*administration & dosage
MH  - Cardiovascular Diseases/*mortality/prevention & control
MH  - Cohort Studies
MH  - *Diet
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasms/*mortality/prevention & control
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Reactive Oxygen Species/metabolism
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Smoking
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - All-cause and cause-specific mortality
OT  - E3N study
OT  - FRAP
OT  - Non-enzymatic antioxidant capacity
OT  - TRAP
EDAT- 2016/02/19 06:00
MHDA- 2017/08/24 06:00
CRDT- 2016/02/19 06:00
PHST- 2015/09/25 00:00 [received]
PHST- 2016/02/02 00:00 [accepted]
PHST- 2016/02/19 06:00 [pubmed]
PHST- 2017/08/24 06:00 [medline]
PHST- 2016/02/19 06:00 [entrez]
AID - 10.1007/s00394-016-1172-6 [pii]
AID - 10.1007/s00394-016-1172-6 [doi]
PST - ppublish
SO  - Eur J Nutr. 2017 Apr;56(3):1233-1243. doi: 10.1007/s00394-016-1172-6. Epub 2016 
      Feb 18.