PMID- 26888804
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20181202
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 43
IP  - 11
DP  - 2015 Nov
TI  - [Relationship between hyperhomocysteine and long-term outcome of coronary artery 
      disease patients after drug-eluting stent implantation].
PG  - 943-7
AB  - OBJECTIVE: To explore the relationship between hyperhomocysteinemia (H-Hcy) and 
      long-term outcome of coronary artery disease (CAD) patients after drug-eluting 
      stent (DES) implantation in a single centre. METHODS: A total of 1 408 
      consecutive patients implanted with DES in our department between March 2011 and 
      January 2013 were enrolled in this prospective study. Patients were stratified 
      into H-Hcy (Hcy>/=10 micromol/L, n=798, 56.7%) and non-H-Hcy group (Hcy<10 micromol/L, 
      n=610, 43.3%). The clinical characteristics, coronary artery lesions, SYNTAX 
      score and 1-year major adverse cardiac and cerebrovascular events (MACCE) were 
      compared between the two groups. RESULTS: Compared with non-H-Hcy group, coronary 
      artery stenosis was severer as shown by higher diseased arteries (2.11+/-0.87 vs. 
      1.91+/-0.82, P<0.001), higher incidence of three diseased arteries (39.7% vs. 
      29.5%, P<0.001) and higher SYNTAX score (36.99+/-29.66 vs. 27.39+/-22.70, P=0.001) in 
      H-Hcy group. The 1-year incidence of MACCE was also higher in H-Hcy group 
      compared with non-H-Hcy group(18.4% vs. 8.9%, P<0.001). Multivariate Cox analysis 
      showed that diabetes mellitus (OR=1.530, 95%CI 1.142-2.050, P=0.004), age 
      (OR=1.065, 95%CI 1.038-1.093; P<0.001), and Hcy (OR=1.019, 95%CI 1.005-1.033, 
      P=0.009) are the independent predictors for 1-year MACCE. CONCLUSION: High Hcy 
      level is correlated with the severity of coronary artery stenosis, and serves as 
      an independent predictor of MACCE after stenting in CAD patients.
FAU - Yan, Gaoliang
AU  - Yan G
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Wang, Dong
AU  - Wang D
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Qiao, Yong
AU  - Qiao Y
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Kong, Wenjie
AU  - Kong W
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Sha, Xiang
AU  - Sha X
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Cheng, Tianyu
AU  - Cheng T
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Zhang, Hairong
AU  - Zhang H
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Hou, Jiantong
AU  - Hou J
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
FAU - Tang, Chengchun
AU  - Tang C
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China; Email: tangchengchun@medmail.com.cn.
FAU - Ma, Genshan
AU  - Ma G
AD  - Department of Cardiology, Zhongda Hospital of Southeast University Medical 
      School, Nanjing 210009, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - *Coronary Artery Disease
MH  - *Drug-Eluting Stents
MH  - Homocysteine
MH  - Humans
MH  - Prospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2016/02/19 06:00
MHDA- 2016/09/16 06:00
CRDT- 2016/02/19 06:00
PHST- 2016/02/19 06:00 [entrez]
PHST- 2016/02/19 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2015 Nov;43(11):943-7.