PMID- 26890368
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20180109
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 88
IP  - 9
DP  - 2016 Sep
TI  - TNF-alpha and IL-10 polymorphisms increase the risk to hepatocellular carcinoma in 
      HCV infected individuals.
PG  - 1587-95
LID - 10.1002/jmv.24501 [doi]
AB  - Hepatitis C virus (HCV) is the major cause of hepatocellular carcinoma (HCC). The 
      risk to develop HCC increases with the severity of liver inflammation and hepatic 
      fibrosis. It is believed that a balance between the releases of pro- and 
      anti-inflammatory cytokines will determine the clinical course of HCV and the 
      risk to develop HCC. The inteleukin-10 (IL-10) and the tumor necrosis factor 
      alpha (TNF-alpha) play key roles in the Th1 and Th2 balance during the inflammatory 
      response against HCV. The aim of the present study was to investigate the 
      association between polymorphisms in TNF-alpha -308 G>A (rs1800629), IL-10 -1082 G>A 
      (rs1800896) and -819/-592 (rs1800871/rs1800872) with HCC risk in individuals with 
      HCV. The present study evaluated 388 chronic HCV patients. Polymorphisms were 
      determined by real-time PCR. Diplotypes associated with low IL-10 production and 
      the TNF-alpha GG genotype were significantly associated with HCC occurrence after 
      multivariate logistic regression analysis (P = 0.027 and P = 0.029, 
      respectively). Additionally, the IL-10 -819 (-592) TT (AA) genotype was 
      significantly associated with multiple nodules and HCC severity according to BCLC 
      staging (P = 0.044 and P = 0.025, respectively). Patients carrying low production 
      haplotypes of IL-10 and the TNF-alpha GG genotype have higher risk to develop HCC. J. 
      Med. Virol. 88:1587-1595, 2016. (c) 2016 Wiley Periodicals, Inc.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Aroucha, Dayse Celia
AU  - Aroucha DC
AD  - Instituto do Figado de Pernambuco (IFP), Recife, Brasil.
AD  - Faculdade de Ciencias Medicas (FCM), Universidade de Pernambuco (UPE), Recife, 
      Brasil.
FAU - Carmo, Rodrigo Feliciano
AU  - Carmo RF
AD  - Colegiado de Farmacia, Universidade Federal do Vale do Sao Francisco (UNIVASF), 
      Petrolina, Brasil.
AD  - Rede Nordeste de Biotecnologia (RENORBIO), Recife, Brasil.
FAU - Vasconcelos, Luydson Richardson Silva
AU  - Vasconcelos LR
AD  - Instituto do Figado de Pernambuco (IFP), Recife, Brasil.
AD  - Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhaes (CPqAM), 
      Fundacao Oswaldo Cruz (FIOCRUZ), Recife, Brasil.
FAU - Lima, Raul Emidio
AU  - Lima RE
AD  - Instituto de Ciencias Biologicas (ICB), Universidade de Pernambuco (UPE), Recife, 
      Brasil.
FAU - Mendonca, Taciana Furtado
AU  - Mendonca TF
AD  - Rede Nordeste de Biotecnologia (RENORBIO), Recife, Brasil.
FAU - Arnez, Lucia Elena
AU  - Arnez LE
AD  - Laboratorio de Hanseniase, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz 
      (FIOCRUZ), Rio de Janeiro, Brasil.
FAU - Cavalcanti, Maria do Socorro Mendonca
AU  - Cavalcanti Mdo S
AD  - Instituto de Ciencias Biologicas (ICB), Universidade de Pernambuco (UPE), Recife, 
      Brasil.
FAU - Muniz, Maria Tereza Cartaxo
AU  - Muniz MT
AD  - Instituto de Ciencias Biologicas (ICB), Universidade de Pernambuco (UPE), Recife, 
      Brasil.
FAU - Aroucha, Marcilio Lins
AU  - Aroucha ML
AD  - Centro de Ciencias da Saude (CCS), Universidade Federal de Pernambuco (UFPE), 
      Brazil.
FAU - Siqueira, Erika Rabelo
AU  - Siqueira ER
AD  - Instituto do Figado de Pernambuco (IFP), Recife, Brasil.
FAU - Pereira, Luciano Beltrao
AU  - Pereira LB
AD  - Instituto do Figado de Pernambuco (IFP), Recife, Brasil.
FAU - Moura, Patricia
AU  - Moura P
AD  - Instituto de Ciencias Biologicas (ICB), Universidade de Pernambuco (UPE), Recife, 
      Brasil.
FAU - Pereira, Leila Maria Moreira Beltrao
AU  - Pereira LM
AD  - Instituto do Figado de Pernambuco (IFP), Recife, Brasil.
AD  - Faculdade de Ciencias Medicas (FCM), Universidade de Pernambuco (UPE), Recife, 
      Brasil.
FAU - Coelho, Maria Rosangela
AU  - Coelho MR
AD  - Setor de Virologia do Laboratorio de Imunopatologia Keizo-Asami (LIKA), 
      Universidade Federal de Pernambuco (UFPE), Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160321
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (IL10 protein, human)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/*genetics/*immunology/virology
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Hepacivirus/immunology
MH  - Hepatitis C, Chronic/complications/*immunology
MH  - Humans
MH  - Inflammation
MH  - Interleukin-10/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
OTO - NOTNLM
OT  - cytokines
OT  - hepatitis c virus
OT  - inflammation
OT  - interleukin
EDAT- 2016/02/19 06:00
MHDA- 2017/08/09 06:00
CRDT- 2016/02/19 06:00
PHST- 2016/02/13 00:00 [accepted]
PHST- 2016/02/19 06:00 [entrez]
PHST- 2016/02/19 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
AID - 10.1002/jmv.24501 [doi]
PST - ppublish
SO  - J Med Virol. 2016 Sep;88(9):1587-95. doi: 10.1002/jmv.24501. Epub 2016 Mar 21.