PMID- 26890611
OWN - NLM
STAT- MEDLINE
DCOM- 20161220
LR  - 20220409
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 51
IP  - 2
DP  - 2016
TI  - Course and Determinants of Anosognosia in Alzheimer's Disease: A 12-Month 
      Follow-up.
PG  - 357-66
LID - 10.3233/JAD-150706 [doi]
AB  - Anosognosia in Alzheimer's disease (AD) has been associated with greater 
      cognitive impairment and more behavioural and psychological symptoms of dementia 
      (BPSD). This study examines the incidence, persistence, and remission rates of 
      anosognosia over a 12-month period, as well as the related risk factors. This was 
      an observational 12-month prospective study. The longitudinal sample comprised 
      177 patients with mild or moderate AD, and their respective caregivers. 
      Anosognosia was assessed using the Anosognosia Questionnaire in Dementia, and we 
      also evaluated cognitive status (Mini-Mental State Examination), functional 
      disability (Disability Assessment in Dementia), and the presence of BPSD 
      (Neuropsychiatric Inventory). Multinomial logistic regression was used to 
      determine the variables associated with the incidence, persistence and remission 
      of anosognosia. The prevalence of anosognosia was 39.5% (95% CI = 32.1-47.1) at 
      baseline. At 12 months, incidence was 38.3% (95% CI = 28.6-48.0), persistence was 
      80.0% (95% CI = 69.9-90.1) and remission was 20.0% (95% CI = 9.9-30.1). The 
      regression model identified lower age, more education, and the presence of 
      delusions as variables associated with incidence, and more education, lower 
      instrumental DAD score, and disinhibition as variables associated with 
      persistence. No variables were associated with remission (n = 14). The presence 
      of anosognosia in AD patients is high. Education and certain neuropsychiatric 
      symptoms may explain a greater and earlier incidence of anosognosia. However, 
      anosognosia also increases with greater cognitive impairment and disease 
      severity.
FAU - Turro-Garriga, Oriol
AU  - Turro-Garriga O
AD  - Health, Aging and Disability Research Group, Girona Biomedical Research Institute 
      (IDIBGI), Girona, Catalonia-Spain.
AD  - Department of Neurology, Institut d'Assistencia Sanitaria-Institut Catala de 
      Salut de Girona, Salt, Catalonia-Spain.
FAU - Garre-Olmo, Josep
AU  - Garre-Olmo J
AD  - Health, Aging and Disability Research Group, Girona Biomedical Research Institute 
      (IDIBGI), Girona, Catalonia-Spain.
AD  - Department of Medical Sciences, University of Girona, Girona, Catalonia-Spain.
FAU - Calvo-Perxas, Laia
AU  - Calvo-Perxas L
AD  - Health, Aging and Disability Research Group, Girona Biomedical Research Institute 
      (IDIBGI), Girona, Catalonia-Spain.
FAU - Rene-Ramirez, Ramon
AU  - Rene-Ramirez R
AD  - Dementia Unit, Department of Neurology, Bellvitge University Hospital, Hospitalet 
      de Llobregat, Catalonia-Spain.
FAU - Gascon-Bayarri, Jordi
AU  - Gascon-Bayarri J
AD  - Dementia Unit, Department of Neurology, Bellvitge University Hospital, Hospitalet 
      de Llobregat, Catalonia-Spain.
FAU - Conde-Sala, Josep Lluis
AU  - Conde-Sala JL
AD  - Health, Aging and Disability Research Group, Girona Biomedical Research Institute 
      (IDIBGI), Girona, Catalonia-Spain.
AD  - Faculty of Psychology, University of Barcelona, Barcelona, Catalonia-Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Agnosia/diagnosis/*epidemiology/*etiology
MH  - Alzheimer Disease/*complications/diagnosis/*epidemiology
MH  - Disability Evaluation
MH  - Disease Progression
MH  - Educational Status
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Status Schedule
MH  - Neuropsychological Tests
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - anosognosia
OT  - caregivers
OT  - dementia
OT  - epidemiological dementia study
OT  - incidence
OT  - insight
OT  - longitudinal studies
OT  - neuropsychiatric disorders
EDAT- 2016/02/19 06:00
MHDA- 2016/12/21 06:00
CRDT- 2016/02/19 06:00
PHST- 2016/02/19 06:00 [entrez]
PHST- 2016/02/19 06:00 [pubmed]
PHST- 2016/12/21 06:00 [medline]
AID - JAD150706 [pii]
AID - 10.3233/JAD-150706 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2016;51(2):357-66. doi: 10.3233/JAD-150706.