PMID- 26890789
OWN - NLM
STAT- MEDLINE
DCOM- 20160726
LR  - 20220316
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 2
DP  - 2016
TI  - Hypoglycemia and Medical Expenses in Patients with Type 2 Diabetes Mellitus: An 
      Analysis Based on the Korea National Diabetes Program Cohort.
PG  - e0148630
LID - 10.1371/journal.pone.0148630 [doi]
LID - e0148630
AB  - BACKGROUND AND AIMS: Hypoglycemia is one of the most important adverse events in 
      individuals with type 2 diabetes mellitus (T2DM). However, hypoglycemia-related 
      events are usually overlooked and have been documented less in clinical practice. 
      MATERIALS AND METHODS: We evaluated the incidence, clinical characteristics, and 
      medical expenses of hypoglycemia related events in T2DM patients based on the 
      Korea National Diabetes Program (KNDP), which is the largest multi-center, 
      prospective cohort in Korea (n = 4,350). For accurate outcomes, the KNDP data 
      were merged with claims data from the Health Insurance Review and Assessment 
      Service (HIRA) of Korea. RESULTS: During a median follow-up period of 3.23 years 
      (95% CI: 3.14, 3.19), 88 subjects (2.02%) were newly diagnosed with hypoglycemia, 
      and the incidence of hypoglycemia was 6.44 cases per 1,000 person-years (PY). 
      Individuals with hypoglycemia were significantly older (59.7+/-10.7 vs. 53.3+/-10.4 
      years, p < 0.001), had more hospital visits (121.94+/-126.88 days/PY, p < 0.001), 
      had a longer hospital stays (16.13+/-29.21 days/PY, p < 0.001), and incurred 
      greater medical costs ($2,447.56+/-4,056.38 vs. $1,336.37+/-3,403.39 /PY, p < 0.001) 
      than subjects without hypoglycemia. CONCLUSION: Hypoglycemia-related events were 
      infrequently identified among the medical records of T2DM subjects. However, they 
      were associated significantly with poor clinical outcomes, and thus, hypoglycemia 
      could have a substantial burden on the Korean national healthcare system.
FAU - Rhee, Sang Youl
AU  - Rhee SY
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Hong, Soo Min
AU  - Hong SM
AD  - Department of Endocrinology and Metabolism, Graduate School of Medicine, Kyung 
      Hee University, Seoul, Korea.
FAU - Chon, Suk
AU  - Chon S
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Ahn, Kyu Jeung
AU  - Ahn KJ
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Kim, Sung Hoon
AU  - Kim SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Cheil 
      General Hospital & Women's Healthcare Center, Dankook University College of 
      Medicine, Seoul, Korea.
FAU - Baik, Sei Hyun
AU  - Baik SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea 
      University College of Medicine, Seoul, Korea.
FAU - Park, Yong Soo
AU  - Park YS
AD  - Department of Internal Medicine, Hanyang University College of Medicine, Guri, 
      Korea.
FAU - Nam, Moon Suk
AU  - Nam MS
AD  - Department of Internal Medicine, Inha University School of Medicine, Incheon, 
      Korea.
FAU - Lee, Kwan Woo
AU  - Lee KW
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Korea.
FAU - Woo, Jeong-Taek
AU  - Woo JT
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Kim, Young Seol
AU  - Kim YS
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20160218
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/complications/diagnosis/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Health Care Costs/*statistics & numerical data
MH  - Humans
MH  - Hypoglycemia/diagnosis/*epidemiology/etiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea/epidemiology
PMC - PMC4758656
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/02/20 06:00
MHDA- 2016/07/28 06:00
PMCR- 2016/02/18
CRDT- 2016/02/19 06:00
PHST- 2015/03/26 00:00 [received]
PHST- 2015/12/11 00:00 [accepted]
PHST- 2016/02/19 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
PHST- 2016/02/18 00:00 [pmc-release]
AID - PONE-D-15-13155 [pii]
AID - 10.1371/journal.pone.0148630 [doi]
PST - epublish
SO  - PLoS One. 2016 Feb 18;11(2):e0148630. doi: 10.1371/journal.pone.0148630. 
      eCollection 2016.