PMID- 26892104
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1873-0329 (Electronic)
IS  - 1383-5769 (Linking)
VI  - 65
IP  - 5 Pt B
DP  - 2016 Oct
TI  - In vivo assay of IgE activities on the expulsion of intestinal adult worms.
PG  - 506-509
LID - S1383-5769(16)30009-5 [pii]
LID - 10.1016/j.parint.2016.02.005 [doi]
AB  - A physiological role of immunoglobulin E (IgE) is to promote parasitic helminth 
      expulsion. This assertion is largely based on a series of studies carried out by 
      Capron's laboratory. They observed that IgE is an essential component of 
      protective immunity against Schistosoma mansoni larvae both in vitro and in vivo. 
      Then, another group reported that IgE-deficient mice show higher worm burdens 
      than wild-type (WT) mice when mice are infected with Trichinella spiralis. 
      Although these studies indicate anti-helminth activities of IgE targeted on 
      larvae forms, they do not prove the fighting effects of IgE on adult worms. In 
      contrast, a recent study demonstrates an expelling activity of IgE for adult 
      worms through an adoptive transfer of immune serum-derived IgE into Strongyloides 
      venezuelensis-infected mice. Here, I describe how IgE is purified from S. 
      venezuelensis-immune sera and is transferred into infected mice to examine its 
      effect on worm expulsion. This method will be used to advance our understanding 
      the mechanism of S. venezuelensis expulsion and explore S. venezuelensis antigens 
      recognized by IgE. Moreover, adoptive transfers of IgE purified from immune sera 
      will be applicable to other helminth infection models to investigate 
      physiological roles of IgE.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Matsumoto, Makoto
AU  - Matsumoto M
AD  - Department of Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 
      Nishinomiya, Hyogo 663-8501, Japan. Electronic address: 
      makoto.matsumo.irkr@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160215
PL  - Netherlands
TA  - Parasitol Int
JT  - Parasitology international
JID - 9708549
OTO - NOTNLM
OT  - Adult worm expulsion
OT  - IgE
OT  - Strongyloides venezuelensis
EDAT- 2016/02/20 06:00
MHDA- 2016/02/20 06:00
CRDT- 2016/02/20 06:00
PHST- 2015/12/29 00:00 [received]
PHST- 2016/02/04 00:00 [revised]
PHST- 2016/02/12 00:00 [accepted]
PHST- 2016/02/20 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2016/02/20 06:00 [medline]
AID - S1383-5769(16)30009-5 [pii]
AID - 10.1016/j.parint.2016.02.005 [doi]
PST - ppublish
SO  - Parasitol Int. 2016 Oct;65(5 Pt B):506-509. doi: 10.1016/j.parint.2016.02.005. 
      Epub 2016 Feb 15.