PMID- 26892325 OWN - NLM STAT- MEDLINE DCOM- 20161011 LR - 20181113 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 15 DP - 2016 Feb 18 TI - Diabetes is an independent predictor of right ventricular dysfunction post ST-elevation myocardial infarction. PG - 34 LID - 10.1186/s12933-016-0352-2 [doi] LID - 34 AB - BACKGROUND: Diabetes mellitus (DM) is estimated to become the 7th leading cause of death by 2030. Right ventricular dysfunction (RVD) complicating ST elevation myocardial infarction (STEMI) is independently associated with a higher mortality; however the relationship between DM and RVD is currently unknown. The purpose of this study was to determine whether DM is an independent predictor for the presence of right ventricular dysfunction (RVD) post STEMI. METHODS: 106 patients post primary PCI for STEMI were enrolled in the study. Cardiac MRI was performed within 48-72 h after admission in order to assess ventricular function. Statistical analysis consisted initially of descriptive statistics including Chi square, Fisher's exact, or the Wilcoxon rank sum as appropriate. Subsequently, logistic regression analysis was performed to determine independent predictors of RVD. RESULTS: The median age in the study was 58 years (IQR 53, 67). 30 % of the patients had diabetes. Of 99 patients for which RV data was available, 40 had RVD and 59 did not. Patients with DM were significantly more likely to have RVD when compared to those without diabetes (45 vs 22 %, p = 0.03). There was no significant difference in age, hypertension, smoking status, dyslipidemia, serum creatinine or peak CK levels between the two groups. After adjusting for other factors, presence of DM remained an independent predictor for the presence of RV dysfunction (OR 2.78, 95 % CI 1.12, 6.87, p = 0.03). Amongst diabetic patients, those with HbA1C >/= 7 % had greater odds of having RVD vs those with HbA1C < 7 % (OR 5.58 (1.20, 25.78), p = 0.02). CONCLUSIONS: The presence of DM conferred an approximately threefold greater odds of being associated with RVD post STEMI. No other major cardiovascular risk factors were independently associated with the presence of RVD. FAU - Roifman, Idan AU - Roifman I AD - Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. idan.roifman@mail.utoronto.ca. FAU - Ghugre, Nilesh AU - Ghugre N AD - Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. nghugre@sri.utoronto.ca. AD - Physical Sciences Platform, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. nghugre@sri.utoronto.ca. AD - Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. nghugre@sri.utoronto.ca. FAU - Zia, Mohammad I AU - Zia MI AD - Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. mo.zia@utoronto.ca. FAU - Farkouh, Michael E AU - Farkouh ME AD - Division of Cardiology, University Health Network, University of Toronto, Toronto, ON, Canada. michael.farkouh@uhn.ca. AD - Keenan Biomedical Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. michael.farkouh@uhn.ca. FAU - Zavodni, Anna AU - Zavodni A AD - Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. anna.zavodni@sunnybrook.ca. FAU - Wright, Graham A AU - Wright GA AD - Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. gawright@sri.utoronto.ca. AD - Physical Sciences Platform, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. gawright@sri.utoronto.ca. AD - Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. gawright@sri.utoronto.ca. FAU - Connelly, Kim A AU - Connelly KA AD - Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. connellyk@smh.ca. AD - Keenan Biomedical Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. connellyk@smh.ca. LA - eng GR - Canadian Institutes of Health Research/Canada PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20160218 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 SB - IM MH - Aged MH - Chi-Square Distribution MH - Diabetes Complications/diagnosis/*etiology/physiopathology MH - Female MH - Humans MH - Logistic Models MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Myocardial Infarction/diagnosis/*therapy MH - Odds Ratio MH - Percutaneous Coronary Intervention/*adverse effects MH - Predictive Value of Tests MH - Prospective Studies MH - Risk Assessment MH - Risk Factors MH - Treatment Outcome MH - Ventricular Dysfunction, Right/diagnosis/*etiology/physiopathology MH - *Ventricular Function, Right PMC - PMC4759780 EDAT- 2016/02/20 06:00 MHDA- 2016/10/12 06:00 PMCR- 2016/02/18 CRDT- 2016/02/20 06:00 PHST- 2015/12/15 00:00 [received] PHST- 2016/02/09 00:00 [accepted] PHST- 2016/02/20 06:00 [entrez] PHST- 2016/02/20 06:00 [pubmed] PHST- 2016/10/12 06:00 [medline] PHST- 2016/02/18 00:00 [pmc-release] AID - 10.1186/s12933-016-0352-2 [pii] AID - 352 [pii] AID - 10.1186/s12933-016-0352-2 [doi] PST - epublish SO - Cardiovasc Diabetol. 2016 Feb 18;15:34. doi: 10.1186/s12933-016-0352-2.