PMID- 2689236
OWN - NLM
STAT- MEDLINE
DCOM- 19900206
LR  - 20220309
IS  - 0748-7983 (Print)
IS  - 0748-7983 (Linking)
VI  - 15
IP  - 6
DP  - 1989 Dec
TI  - Adjuvant radiotherapy and chemotherapy in resectable gastric cancer. A randomized 
      trial of the gastro-intestinal tract cancer cooperative group of the EORTC.
PG  - 535-43
AB  - One hundred and fifteen patients with curative and palliative surgery for gastric 
      cancer were randomized to receive radiotherapy alone (1) or in combination with 
      short-term (ST) 5-FU (2), long-term (LT) 5-FU (3), ST and LT 5-FU (4). The ST 
      5-FU was given at a daily dose of 575 mg/m2, every 4-6 h during the first 4 days 
      of treatment before starting irradiation. The LT 5-FU was given at a dosage of 
      750 mg/m2 every 2 weeks for 18 months or until progression. The median survival 
      times for treatment 1 to 4 was respectively 12, 10, 15 and 18 months. There was a 
      statistically significant overall difference between the four treatments (P = 
      0.041). However, when the comparisons were adjusted for the most significant 
      prognostic factors, the difference in survival disappeared. Moreover, no 
      difference was found between treatments in terms of time progression. 
      Nevertheless, among 22 patients with residual tumour, the three who were still 
      alive without disease progression (with survivals of 19+, 49+ and 90+ months at 
      the time of this analysis) had been treated with radiotherapy combined with ST 
      and LT 5-FU.
FAU - Bleiberg, H
AU  - Bleiberg H
AD  - Institut Jules Bordet, Brussels, Belgium.
FAU - Goffin, J C
AU  - Goffin JC
FAU - Dalesio, O
AU  - Dalesio O
FAU - Buyse, M
AU  - Buyse M
FAU - Pector, J C
AU  - Pector JC
FAU - Gignoux, M
AU  - Gignoux M
FAU - Roussel, A
AU  - Roussel A
FAU - Samana, G
AU  - Samana G
FAU - Michel, J
AU  - Michel J
FAU - Gerard, A
AU  - Gerard A
AU  - et al.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Surg Oncol
JT  - European journal of surgical oncology : the journal of the European Society of 
      Surgical Oncology and the British Association of Surgical Oncology
JID - 8504356
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adenocarcinoma/mortality/pathology/*therapy
MH  - Combined Modality Therapy
MH  - Drug Administration Schedule
MH  - Female
MH  - Fluorouracil/adverse effects/*therapeutic use
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multicenter Studies as Topic
MH  - Postoperative Complications
MH  - Prognosis
MH  - Prospective Studies
MH  - Radiotherapy/adverse effects
MH  - Randomized Controlled Trials as Topic
MH  - Stomach Neoplasms/mortality/pathology/*therapy
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
PST - ppublish
SO  - Eur J Surg Oncol. 1989 Dec;15(6):535-43.