PMID- 26892441
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 29
IP  - 5
DP  - 2016 May
TI  - Intravenous leiomyomatosis: an unusual intermediate between benign and malignant 
      uterine smooth muscle tumors.
PG  - 500-10
LID - 10.1038/modpathol.2016.36 [doi]
AB  - Intravenous leiomyomatosis is an unusual smooth muscle neoplasm with 
      quasi-malignant intravascular growth but a histologically banal appearance. 
      Herein, we report expression and molecular cytogenetic analyses of a series of 12 
      intravenous leiomyomatosis cases to better understand the pathogenesis of 
      intravenous leiomyomatosis. All cases were analyzed for the expression of HMGA2, 
      MDM2, and CDK4 proteins by immunohistochemistry based on our previous finding of 
      der(14)t(12;14)(q14.3;q24) in intravenous leiomyomatosis. Seven of 12 (58%) 
      intravenous leiomyomatosis cases expressed HMGA2, and none expressed MDM2 or 
      CDK4. Colocalization of hybridization signals for probes from the HMGA2 locus 
      (12q14.3) and from 14q24 by interphase fluorescence in situ hybridization (FISH) 
      was detected in a mean of 89.2% of nuclei in HMGA2-positive cases by 
      immunohistochemistry, but in only 12.4% of nuclei in negative cases, indicating 
      an association of HMGA2 expression and this chromosomal rearrangement (P=8.24 x 
      10(-10)). Four HMGA2-positive cases had greater than two HMGA2 hybridization 
      signals per cell. No cases showed loss of a hybridization signal by interphase 
      FISH for the frequently deleted region of 7q22 in uterine leiomyomata. One 
      intravenous leiomyomatosis case analyzed by array comparative genomic 
      hybridization revealed complex copy number variations. Finally, expression 
      profiling was performed on three intravenous leiomyomatosis cases. Interestingly, 
      hierarchical cluster analysis of the expression profiles revealed segregation of 
      the intravenous leiomyomatosis cases with leiomyosarcoma rather than with 
      myometrium, uterine leiomyoma of the usual histological type, or plexiform 
      leiomyoma. These findings suggest that intravenous leiomyomatosis cases share 
      some molecular cytogenetic characteristics with uterine leiomyoma, and expression 
      profiles similar to that of leiomyosarcoma cases, further supporting their 
      intermediate, quasi-malignant behavior.
FAU - Ordulu, Zehra
AU  - Ordulu Z
AD  - Departments of Obstetrics, Gynecology and Reproductive Biology, Brigham and 
      Women's Hospital, Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Nucci, Marisa R
AU  - Nucci MR
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
AD  - Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, 
      Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Dal Cin, Paola
AU  - Dal Cin P
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Hollowell, Monica L
AU  - Hollowell ML
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
AD  - Department of Pathology, Baystate Medical Center, Springfield, MA, USA.
FAU - Otis, Christopher N
AU  - Otis CN
AD  - Department of Pathology, Baystate Medical Center, Springfield, MA, USA.
FAU - Hornick, Jason L
AU  - Hornick JL
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Park, Peter J
AU  - Park PJ
AD  - Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
FAU - Kim, Tae-Min
AU  - Kim TM
AD  - Departments of Medical Informatics and Cancer Evolution Research Center, College 
      of Medicine, The Catholic University of Korea, Seoul, South Korea.
FAU - Quade, Bradley J
AU  - Quade BJ
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
AD  - Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, 
      Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Morton, Cynthia C
AU  - Morton CC
AD  - Departments of Obstetrics, Gynecology and Reproductive Biology, Brigham and 
      Women's Hospital, Boston, MA, USA.
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
AD  - Broad Institute of MIT and Harvard, Cambridge, MA, USA.
LA  - eng
GR  - P30 CA006516/CA/NCI NIH HHS/United States
GR  - R01 CA078895/CA/NCI NIH HHS/United States
GR  - R01 HD060530/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160219
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Cytogenetic Analysis
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Leiomyoma/genetics/pathology
MH  - Leiomyomatosis/genetics/*pathology
MH  - Smooth Muscle Tumor/genetics/*pathology
MH  - *Transcriptome
MH  - Uterine Neoplasms/genetics/pathology
MH  - Vascular Neoplasms/genetics/*pathology
PMC - PMC5891726
MID - NIHMS750860
COIS- DISCLOSURE/CONFLICT OF INTEREST The authors declare no conflicts of interest.
EDAT- 2016/02/20 06:00
MHDA- 2018/01/03 06:00
PMCR- 2018/04/10
CRDT- 2016/02/20 06:00
PHST- 2015/10/11 00:00 [received]
PHST- 2016/01/09 00:00 [revised]
PHST- 2016/01/10 00:00 [accepted]
PHST- 2016/02/20 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2018/04/10 00:00 [pmc-release]
AID - S0893-3952(22)02129-9 [pii]
AID - 10.1038/modpathol.2016.36 [doi]
PST - ppublish
SO  - Mod Pathol. 2016 May;29(5):500-10. doi: 10.1038/modpathol.2016.36. Epub 2016 Feb 
      19.