PMID- 26892450
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20160329
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 117
IP  - 8
DP  - 2016 Apr 15
TI  - Association of Late Gadolinium Enhancement and Degree of Left Ventricular 
      Hypertrophy Assessed on Cardiac Magnetic Resonance Imaging With Ventricular 
      Tachycardia in Children With Hypertrophic Cardiomyopathy.
PG  - 1342-8
LID - S0002-9149(16)30154-0 [pii]
LID - 10.1016/j.amjcard.2016.01.032 [doi]
AB  - There are limited data on the clinical significance of left ventricular (LV) mass 
      and late gadolinium enhancement (LGE) in pediatric hypertrophic cardiomyopathy 
      (HC). We reviewed cardiovascular magnetic resonance (CMR) studies of children 
      with HC to investigate the associations between the extent and distribution of 
      LGE and LV mass with ventricular tachycardia (VT) in children with HC. A blinded 
      observer reviewed CMR studies for the presence and distribution of LV hypertrophy 
      and LGE using a 17-segment model. The primary outcome was VT. LGE was present 17 
      of 33 subjects (52%). VT was present on outpatient Holter monitor or exercise 
      stress test in 7 patients, of which 5 patients (71%) had LGE. Each additional 
      segment of LGE was associated with an increase in the odds of VT (odds ratio [OR] 
      1.4, 95% CI 1.1 to 1.9) and fewer than 5 segments with LGE had 93% specificity 
      for the presence or absence of VT (OR 0.06, 95% CI 0.01 to 0.5). VT was more 
      common in patients with LGE in the apical septal (p = 0.03), basal inferoseptal 
      (p <0.01), and basal inferior (p = 0.04) segments, whereas LGE in more commonly 
      involved segments (midanteroseptal and midinferoseptal) was not associated with 
      VT (p = 0.13, 0.26). Patients with VT had greater LV mass index (76.4 +/- 
      40.4 g/m(2.7) vs 50.9 +/- 24.3 g/m(2.7); p = 0.03). Each centimeter of increased 
      maximum LV thickness was associated with increased likelihood of VT (OR 2.9, 95% 
      CI 1.2 to 6.8). In conclusion, in pediatric HC, CMR to evaluate the extent and 
      pattern of LGE, LV mass index, and maximum LV thickness may help to identify 
      children with HC at risk of VT.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Spinner, Joseph A
AU  - Spinner JA
AD  - Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of 
      Medicine, Houston, TX.
FAU - Noel, Cory V
AU  - Noel CV
AD  - Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of 
      Medicine, Houston, TX.
FAU - Denfield, Susan W
AU  - Denfield SW
AD  - Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of 
      Medicine, Houston, TX.
FAU - Krishnamurthy, Rajesh
AU  - Krishnamurthy R
AD  - EB Singleton Department of Radiology, Texas Children's Hospital, Baylor College 
      of Medicine, Houston, TX.
FAU - Jeewa, Aamir
AU  - Jeewa A
AD  - Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of 
      Medicine, Houston, TX.
FAU - Dreyer, William J
AU  - Dreyer WJ
AD  - Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of 
      Medicine, Houston, TX.
FAU - Maskatia, Shiraz A
AU  - Maskatia SA
AD  - Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of 
      Medicine, Houston, TX. Electronic address: samaskat@bcm.edu.
LA  - eng
PT  - Journal Article
DEP - 20160128
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Cardiomyopathy, Hypertrophic/*complications/diagnosis/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Contrast Media/pharmacology
MH  - Disease Progression
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Follow-Up Studies
MH  - Gadolinium DTPA/*pharmacology
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*complications/diagnosis/physiopathology
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Stroke Volume/*physiology
MH  - Tachycardia, Ventricular/*diagnosis/etiology/physiopathology
EDAT- 2016/02/20 06:00
MHDA- 2016/08/10 06:00
CRDT- 2016/02/20 06:00
PHST- 2015/11/19 00:00 [received]
PHST- 2016/01/18 00:00 [revised]
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/02/20 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
AID - S0002-9149(16)30154-0 [pii]
AID - 10.1016/j.amjcard.2016.01.032 [doi]
PST - ppublish
SO  - Am J Cardiol. 2016 Apr 15;117(8):1342-8. doi: 10.1016/j.amjcard.2016.01.032. Epub 
      2016 Jan 28.