PMID- 26893786
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 11
IP  - 2
DP  - 2016 Feb
TI  - MicroRNA-26a induces osteosarcoma cell growth and metastasis via the 
      Wnt/beta-catenin pathway.
PG  - 1592-1596
AB  - MicroRNAs (miRNAs/miRs) are a type of highly conserved, small non-coding RNA that 
      are vital to the post-transcriptional regulation of gene expression via base 
      pairing with target mRNA 3'-untranslated regions (3'-UTRs). Several studies have 
      indicated that the abnormal expression of miRNAs occurs frequently in human 
      osteosarcoma (OS). In the present study, the role of miR-26a in the progression 
      and metastasis of OS was investigated using reverse transcription-quantitative 
      polymerase chain reaction, a luciferase activity assay, cell viability assay, in 
      vitro migration and invasion assays, transfection and western blot analysis. 
      miR-26a was upregulated in OS tissues and cell lines, and the expression of 
      miR-26a was indicated to affect the proliferation, migration and invasion of OS 
      Saos-2 cells. At the molecular level, the results showed that glycogen synthase 
      kinase-3beta (GSK-3beta) was identified as a target of miR-26a, and the ectopic 
      expression of miR-26a inhibited GSK-3beta by directly binding to the 3'-UTR. 
      Therefore, the expression of miR-26a was negatively correlated with GSK-3beta in the 
      OS tissues. These data suggest that miR-26a is significant in the proliferation 
      of human OS cells due to the direct regulation of Wnt/beta-catenin signaling.
FAU - Qu, Feng
AU  - Qu F
AD  - Department of Orthopedics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing 100730, P.R. China; Department of Orthopedics, Chinese People's 
      Liberation Army General Hospital, Beijing 100853, P.R. China.
FAU - Li, Chun-Bao
AU  - Li CB
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
FAU - Yuan, Bang-Tuo
AU  - Yuan BT
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
FAU - Qi, Wei
AU  - Qi W
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
FAU - Li, Hong-Liang
AU  - Li HL
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
FAU - Shen, Xue-Zhen
AU  - Shen XZ
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
FAU - Zhao, Gang
AU  - Zhao G
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
FAU - Wang, Jiang-Tao
AU  - Wang JT
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
FAU - Liu, Yu-Jie
AU  - Liu YJ
AD  - Department of Orthopedics, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20151231
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4734282
OTO - NOTNLM
OT  - cell proliferation
OT  - glycogen synthase kinase-3beta
OT  - microRNA-26a
OT  - microRNAs
OT  - osteosarcoma
EDAT- 2016/02/20 06:00
MHDA- 2016/02/20 06:01
PMCR- 2015/12/31
CRDT- 2016/02/20 06:00
PHST- 2015/02/27 00:00 [received]
PHST- 2015/12/04 00:00 [accepted]
PHST- 2016/02/20 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2016/02/20 06:01 [medline]
PHST- 2015/12/31 00:00 [pmc-release]
AID - OL-0-0-4073 [pii]
AID - 10.3892/ol.2015.4073 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Feb;11(2):1592-1596. doi: 10.3892/ol.2015.4073. Epub 2015 Dec 
      31.