PMID- 26894850
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20170918
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1015-1016
DP  - 2016 Mar 15
TI  - A multi-residue method for simultaneous determination of 74 pesticides in Chinese 
      material medica using modified QuEChERS sample preparation procedure and gas 
      chromatography tandem mass spectrometry.
PG  - 1-12
LID - S1570-0232(16)30036-8 [pii]
LID - 10.1016/j.jchromb.2016.01.029 [doi]
AB  - The present study is focused on the development of an analytical method for the 
      simultaneous analysis of seventy-four pesticides belonging to different chemical 
      classes (organochlorines, organophosphates, pyrethroids, dinitroanilines, 
      dicarboximides, triazoles, etc.) in Chinese material medica. The samples were 
      extracted according to the acetate QuEChERS protocol. To reduce the amount of 
      co-extracted compounds, n-hexane instead of acetonitrile was employed as the 
      extraction solvent. To improve the overall recoveries of problematic basic and 
      base-sensitive compounds, sodium acetate was used to adjust the pH to a neutral 
      condition, and florisil combined with octadecyl-modified silica (C18) were 
      utilized in the cleanup step. The samples were analysed by GC-MS/MS, and 
      quantified by matrix-matched calibration. The validation study was carried out on 
      two representative herbs, Chuanxiong Rhizoma and Angelica Sinensis Radix. In two 
      matrices, the linearity of the calibration was good between 5 and 250 ng/mL 
      concentration ranges, and the limits of quantification (LOQs) less than 0.01 
      mg/kg for most pesticides. At the LOQs and ten times the LOQs, the mean 
      recoveries of almost all pesticides were within 70-120%, with relative standard 
      deviations (RSDs) lower than 10%. The method was applied on twenty real samples. 
      Seven batches of Chuanxiong and five batches of Danggui were found to contain the 
      residues. The combination of modified QuEChERS and GC-MS/MS offers low cost of 
      analysis as well as excellent accuracy and sensitivity. This method could be 
      especially useful for trace analysis of pesticide residues in complex matrices.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Liu, Xiao-Qin
AU  - Liu XQ
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Li, Yun-Fei
AU  - Li YF
AD  - Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300402, China.
FAU - Meng, Wen-Ting
AU  - Meng WT
AD  - Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300402, China.
FAU - Li, Dong-Xiang
AU  - Li DX
AD  - Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300402, China.
FAU - Sun, Henry
AU  - Sun H
AD  - Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300402, China.
FAU - Tong, Ling
AU  - Tong L
AD  - Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300402, China. 
      Electronic address: ling_tong1704@sina.com.
FAU - Sun, Guo-Xiang
AU  - Sun GX
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. 
      Electronic address: guoxiang_sun416@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160201
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Pesticide Residues)
SB  - IM
MH  - Drugs, Chinese Herbal/*analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Linear Models
MH  - Pesticide Residues/*analysis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Angelica sinensis radix
OT  - Chuanxiong rhizoma
OT  - GC-MS/MS
OT  - Pesticide residues
OT  - QuEChERS
EDAT- 2016/02/20 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/20 06:00
PHST- 2015/09/10 00:00 [received]
PHST- 2016/01/09 00:00 [revised]
PHST- 2016/01/19 00:00 [accepted]
PHST- 2016/02/20 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1570-0232(16)30036-8 [pii]
AID - 10.1016/j.jchromb.2016.01.029 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:1-12. doi: 
      10.1016/j.jchromb.2016.01.029. Epub 2016 Feb 1.