PMID- 26895195
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20181202
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 51
IP  - 8
DP  - 2016 Aug
TI  - Single Breath-Hold T1rho-Mapping of the Heart for Endogenous Assessment of 
      Myocardial Fibrosis.
PG  - 505-12
LID - 10.1097/RLI.0000000000000261 [doi]
AB  - OBJECTIVES: In this study, we propose a method to acquire high spatial-resolution 
      T1rho-maps, which allows bright and black-blood imaging, in a single breath-hold. 
      To validate this innovative method, the reproducibility was tested in phantoms 
      and volunteers. Lastly, the sensitivity and specificity for infarct detection was 
      compared with the criterion standard late gadolinium enhancement (LGE). METHODS: 
      T1rho-mapping was performed using a T1rho-prepared balanced steady-state free 
      precession sequence at 1.5 T and 3 T. Five images with increasing spin-lock 
      preparation times (spin-lock = 0, 10, 20, 30, 40 milliseconds, amplitude = 500 
      Hz) were acquired with an interval of 3 beats. Black-blood imaging was performed 
      using a double inversion pulse sequence. The method was tested in 2 times 10 
      healthy volunteers at 1.5 and 3 T and in 9 myocardial infarction patients at 1.5 
      T. T1rho-maps, and LGE images were scored for presence and extent of myocardial 
      scarring. RESULTS: Phantom results show that the proposed T1rho-mapping method 
      gives accurate T1rho-values. The mean T1rho-relaxation time of the myocardium in 
      healthy controls was 52.8 +/- 1.8 milliseconds at 1.5 T and 46.4 +/- 1.8 milliseconds 
      at 3 T. In patients, the T1rho of infarcted myocardium was (82.4 +/- 5.2 
      milliseconds), and the T1rho of remote myocardium was (54.2 +/- 2.8 milliseconds; P < 
      0.0001). Sensitivity of infarct detection on a T1rho-map was 70%, with a 
      specificity of 94%, compared with LGE. CONCLUSIONS: In this study, we have 
      investigated a method to acquire high spatial-resolution T1rho-maps of the heart in 
      a single breath-hold. This method proved to be reproducible and had high 
      specificity compared with LGE and can thus be used for the endogenous detection 
      of myocardial fibrosis in patients with ischemic cardiomyopathy.
FAU - van Oorschot, Joep W M
AU  - van Oorschot JW
AD  - From the *Department of Radiology, University Medical Center Utrecht, Utrecht; 
      daggerPhilips Healthcare, Best; and double daggerDepartment of Cardiology, University Medical 
      Center Utrecht, Utrecht, the Netherlands.
FAU - Visser, Fredy
AU  - Visser F
FAU - Eikendal, Anouk L M
AU  - Eikendal AL
FAU - Vonken, Evert-Jan P A
AU  - Vonken EJ
FAU - Luijten, Peter R
AU  - Luijten PR
FAU - Chamuleau, Steven A J
AU  - Chamuleau SA
FAU - Leiner, Tim
AU  - Leiner T
FAU - Zwanenburg, Jaco J M
AU  - Zwanenburg JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - *Breath Holding
MH  - Female
MH  - Fibrosis
MH  - Gadolinium
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Myocardial Infarction/*diagnostic imaging/*pathology
MH  - Myocardium/*pathology
MH  - Phantoms, Imaging
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2016/02/20 06:00
MHDA- 2017/11/03 06:00
CRDT- 2016/02/20 06:00
PHST- 2016/02/20 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
AID - 10.1097/RLI.0000000000000261 [doi]
PST - ppublish
SO  - Invest Radiol. 2016 Aug;51(8):505-12. doi: 10.1097/RLI.0000000000000261.