PMID- 26895777
OWN - NLM
STAT- MEDLINE
DCOM- 20171228
LR  - 20181202
IS  - 1878-4119 (Electronic)
IS  - 1010-5182 (Linking)
VI  - 44
IP  - 4
DP  - 2016 Apr
TI  - Effects of cisplatin chemotherapy on the osseointegration of titanium implants.
PG  - 337-46
LID - S1010-5182(16)00026-3 [pii]
LID - 10.1016/j.jcms.2016.01.012 [doi]
AB  - PURPOSE: The effect of chemotherapy on the osseointegration of dental implants 
      has received less interest compared with radiotherapy. Thus, the aim of the 
      current study was to investigate the effect of cisplatin chemotherapy on the 
      osseointegration of dental implants in a rabbit model. MATERIALS AND METHODS: 
      Sixteen New Zealand White rabbits were randomly assigned to two groups of 
      treatment of either cisplatin at 2.5 mg/kg/week for 4 weeks (n = 8) or placebo 
      (n = 8), in which the first dose was administered 2 days prior to the surgical 
      procedure. Each rabbit received one titanium dental implant inserted in the right 
      distal femoral condyle. Four rabbits from each group were sacrificed 4 and 8 
      weeks after implant insertion. Osseointegration of the dental implants was 
      analysed using micro-computed tomography and histomorphometric evaluation. 
      RESULTS: Analysis of micro-computed tomography data and histomorphometric data 
      showed that the osseointegration parameters, including the ratio of bone volume 
      to total volume (BV/TV) and bone-implant contact (BIC%) for the cisplatin group, 
      were significantly lower compared to the control group at 4 and 8 weeks. 
      (P </= 0.05). CONCLUSION: Cisplatin chemotherapy had a negative effect on the 
      osseointegration of dental implants when inserted throughout the chemotherapeutic 
      regimens in a rabbit model.
CI  - Copyright (c) 2016 European Association for Cranio-Maxillo-Facial Surgery. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Al-Mahalawy, Haytham
AU  - Al-Mahalawy H
AD  - Biomedical Dental Sciences Department, College of Dentistry, University of 
      Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: 
      haelmahalawy@uod.edu.sa.
FAU - Marei, Hesham F
AU  - Marei HF
AD  - Biomedical Dental Sciences Department, College of Dentistry, University of 
      Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: 
      hmarei@uod.edu.sa.
FAU - Abuohashish, Hatem
AU  - Abuohashish H
AD  - Biomedical Dental Sciences Department, College of Dentistry, University of 
      Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: 
      habuohashish@uod.edu.sa.
FAU - Alhawaj, Hussain
AU  - Alhawaj H
AD  - Center of Research and Medical Consultation, University of Dammam, Dammam, 31441, 
      Saudi Arabia. Electronic address: Haalhawaj@uod.edu.sa.
FAU - Alrefaee, Munir
AU  - Alrefaee M
AD  - Department of Internal Medicine, Oncology & Hematology, College of Medicine, 
      University of Dammam, Dammam, Saudi Arabia. Electronic address: 
      mrefaee@uod.edu.sa.
FAU - Al-Jandan, Badr
AU  - Al-Jandan B
AD  - Biomedical Dental Sciences Department, College of Dentistry, University of 
      Dammam, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: 
      baljandan@uod.edu.sa.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160122
PL  - Scotland
TA  - J Craniomaxillofac Surg
JT  - Journal of cranio-maxillo-facial surgery : official publication of the European 
      Association for Cranio-Maxillo-Facial Surgery
JID - 8704309
RN  - D1JT611TNE (Titanium)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Cisplatin/*pharmacology
MH  - *Dental Implantation, Endosseous
MH  - Osseointegration/*drug effects/physiology
MH  - Rabbits
MH  - Surface Properties
MH  - *Titanium
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - Chemotherapy
OT  - Cisplatin
OT  - Dental implants
OT  - Histomorphometry
OT  - Micro-computed tomography
OT  - Osseointegration
EDAT- 2016/02/21 06:00
MHDA- 2017/12/29 06:00
CRDT- 2016/02/21 06:00
PHST- 2015/08/01 00:00 [received]
PHST- 2015/12/29 00:00 [revised]
PHST- 2016/01/12 00:00 [accepted]
PHST- 2016/02/21 06:00 [entrez]
PHST- 2016/02/21 06:00 [pubmed]
PHST- 2017/12/29 06:00 [medline]
AID - S1010-5182(16)00026-3 [pii]
AID - 10.1016/j.jcms.2016.01.012 [doi]
PST - ppublish
SO  - J Craniomaxillofac Surg. 2016 Apr;44(4):337-46. doi: 10.1016/j.jcms.2016.01.012. 
      Epub 2016 Jan 22.