PMID- 26896599
OWN - NLM
STAT- MEDLINE
DCOM- 20161103
LR  - 20161230
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 21
IP  - 113
DP  - 2016 Jan
TI  - Increase of infiltrating monocytes in the livers of patients with chronic liver 
      diseases.
PG  - 25-33
AB  - Infiltrating monocytes have been demonstrated to contribute to tissue damage in 
      experimental models of liver injury and fibrosis. However, less is known about 
      monocyte infiltration in the livers of patients with chronic liver diseases 
      (CLD). In the present study, we demonstrated that CD68+ hepatic macrophages and 
      MAC387+ infiltrating monocytes were significantly increased in the livers of CLD 
      patients with different etiologies as compared with normal liver tissue. In 
      addition, CLD patients with higher inflammatory grading scores had more CD68+ 
      macrophages and MAC387+ monocytes infiltration in their livers compared to those 
      with lower scores. Significantly more MAC387+ infiltrating monocytes were found 
      in the liver tissue of CLD patients with higher fibrotic staging scores compared 
      to those with lower scores. Monocyte chemoattractant protein-1 (MCP-1) expression 
      was significantly increased in the livers of CLD patients with different 
      etiologies. MCP-1 staining scores were significantly positively associated with 
      the numbers of MAC387+ infiltrating monocytes in CLD patients. Taken together, 
      our results demonstrate that infiltrating monocytes may play a pathological role 
      in exacerbating chronic liver inflammation and fibrosis in CLD. MCP-1 may be 
      involved in the monocyte infiltration and progression of liver inflammation and 
      fibrosis in CLD.
FAU - Huang, Rui
AU  - Huang R
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Wu, Hongyan
AU  - Wu H
AD  - Department of Pathology, Nanjing Drum Tower Hospital, Nanjing University Medical 
      School, Nanjing, Jiangsu 210008, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Yang, Chenchen
AU  - Yang C
AD  - Department of Infectious Diseases, Qidong People's Hospital, Qidong, Jiangsu 
      226200, China.
FAU - Pan, Zhiyun
AU  - Pan Z
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Xia, Juan
AU  - Xia J
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Xiong, Yali
AU  - Xiong Y
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Wang, Guiyang
AU  - Wang G
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Sun, Zhenhua
AU  - Sun Z
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Pathology, Nanjing Drum Tower Hospital, Nanjing University Medical 
      School, Nanjing, Jiangsu 210008, China.
FAU - Yan, Xiaomin
AU  - Yan X
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Zhang, Zhaoping
AU  - Zhang Z
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Wu, Chao
AU  - Wu C
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu 210008, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD/*metabolism
MH  - Antigens, Differentiation, Myelomonocytic/*metabolism
MH  - Chemokine CCL2/*metabolism
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - *Liver/metabolism/pathology
MH  - *Liver Cirrhosis/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - *Monocytes/metabolism/pathology
EDAT- 2016/02/21 06:00
MHDA- 2016/11/04 06:00
CRDT- 2016/02/21 06:00
PHST- 2016/02/21 06:00 [entrez]
PHST- 2016/02/21 06:00 [pubmed]
PHST- 2016/11/04 06:00 [medline]
PST - ppublish
SO  - Discov Med. 2016 Jan;21(113):25-33.