PMID- 26897860
OWN - NLM
STAT- MEDLINE
DCOM- 20160321
LR  - 20160222
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 63
IP  - 10
DP  - 2015 Oct
TI  - [Pathogenesis and Laboratory Findings in Antiphospholipid Syndrome, Especially 
      Associated with Lupus Anticoagulant].
PG  - 1220-7
AB  - Antiphospholipid syndrome (APS), an acquired thrombotic condition, is a complex 
      clinical state characterized by the presence of circulating antiphospholipid 
      antibodies in patients with thrombosis or pregnancy morbidity. Revised APS 
      classification criteria are used for diagnosis, which include at least one 
      clinical criterion (thrombosis or pregnancy loss) and at least one of the 
      laboratory criteria [anticardiolipin antibodies, anti-beta2GPI antibodies, lupus 
      anticoagulant (LA)]. LA is also an independent risk factor for developing 
      thrombosis, though some LA-positive cases have been reported to have a bleeding 
      symptom. Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is a rare 
      disorder characterized by a bleeding tendency due to low prothrombin activity in 
      patients with LA, and has recently been reported not only in children but also in 
      adults We have encountered LA cases with bleeding and low coagulation factor 
      activities except for prothrombin. Based on our findings, we propose that 
      LA-positive cases with a bleeding symptom and characterized by low coagulation 
      factor activity including prothrombin be termed lupus anticoagulant-associated 
      coagulopathy (LAAC). Furthermore, coagulation factor autoantibodies are often 
      detected in LAAC patients; thus, correct measurement of LA is important to 
      distinguish LAAC patients from those possessing an inhibitor to coagulation 
      factors such as acquired hemophilia A as well as to select the optimal 
      therapeutic strategy.
FAU - Ieko, Masahiro
AU  - Ieko M
FAU - Naito, Sumiyoshi
AU  - Naito S
FAU - Yoshida, Mika
AU  - Yoshida M
FAU - Takahashi, Nobuhiko
AU  - Takahashi N
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Lupus Coagulation Inhibitor)
RN  - 9001-26-7 (Prothrombin)
SB  - IM
MH  - Animals
MH  - Antibodies, Antiphospholipid/blood
MH  - Antiphospholipid Syndrome/blood/classification/*diagnosis/*immunology
MH  - Autoantibodies/blood
MH  - Biomarkers/blood
MH  - Clinical Laboratory Techniques/methods
MH  - Diagnosis, Differential
MH  - Humans
MH  - Hypoprothrombinemias/diagnosis
MH  - Lupus Coagulation Inhibitor/*blood
MH  - Prothrombin/immunology
MH  - Risk Factors
MH  - Syndrome
MH  - Thrombosis/diagnosis/etiology
EDAT- 2016/02/24 06:00
MHDA- 2016/03/22 06:00
CRDT- 2016/02/23 06:00
PHST- 2016/02/23 06:00 [entrez]
PHST- 2016/02/24 06:00 [pubmed]
PHST- 2016/03/22 06:00 [medline]
PST - ppublish
SO  - Rinsho Byori. 2015 Oct;63(10):1220-7.