PMID- 26898831 OWN - NLM STAT- MEDLINE DCOM- 20161226 LR - 20161230 IS - 1872-8057 (Electronic) IS - 0303-7207 (Linking) VI - 426 DP - 2016 May 5 TI - A deregulated expression of estrogen-target genes is associated with an altered response to estradiol in aged rats perinatally exposed to bisphenol A. PG - 33-42 LID - S0303-7207(16)30037-5 [pii] LID - 10.1016/j.mce.2016.02.010 [doi] AB - Here we assessed the effects of perinatal exposure to bisphenol A (BPA) on the uterine response to 17beta-estradiol (E2) in aged rats. Pregnant rats were orally exposed to 0.5 or 50 mug BPA/kg/day from gestational day 9 until weaning. On postnatal day (PND) 360, the rats were ovariectomized and treated with E2 for three months. The uterine tissue of BPA50 and BPA0.5 rats showed increased density of glands with squamous metaplasia (GSM) and glands with daughter glands respectively. Wnt7a expression was lower in GSM of BPA50 rats than in controls. The expression of estrogen receptor 1 (ESR1) and its 5'- untranslated exons ESR1-O and ESR1-OT was lower in BPA50 rats. Both doses of BPA modified the expression of coactivator proteins and epigenetic regulatory enzymes. Thus, perinatal BPA-exposed rats showed different glandular abnormalities associated with deregulated expression of E2-target genes. Different mechanisms would be involved depending on the BPA dose administered. CI - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved. FAU - Vigezzi, Lucia AU - Vigezzi L AD - Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina; Catedra de Fisiologia Humana, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina. FAU - Ramos, Jorge G AU - Ramos JG AD - Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina; Departamento de Bioquimica Clinica y Cuantitativa, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina. FAU - Kass, Laura AU - Kass L AD - Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina; Catedra de Patologia Humana, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina. FAU - Tschopp, Maria V AU - Tschopp MV AD - Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina. FAU - Munoz-de-Toro, Monica AU - Munoz-de-Toro M AD - Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina; Catedra de Patologia Humana, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina. FAU - Luque, Enrique H AU - Luque EH AD - Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina; Catedra de Fisiologia Humana, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina. FAU - Bosquiazzo, Veronica L AU - Bosquiazzo VL AD - Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina; Departamento de Bioquimica Clinica y Cuantitativa, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina. Electronic address: vlbosqui@fbcb.unl.edu.ar. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160216 PL - Ireland TA - Mol Cell Endocrinol JT - Molecular and cellular endocrinology JID - 7500844 RN - 0 (Benzhydryl Compounds) RN - 0 (Endocrine Disruptors) RN - 0 (Estrogen Receptor alpha) RN - 0 (Nuclear Receptor Coactivators) RN - 0 (Phenols) RN - 0 (Wnt Proteins) RN - 4TI98Z838E (Estradiol) RN - MLT3645I99 (bisphenol A) SB - IM MH - Animals MH - Benzhydryl Compounds/*toxicity MH - Endocrine Disruptors/*toxicity MH - Estradiol/*pharmacology MH - Estrogen Receptor alpha/genetics/metabolism MH - Female MH - Gene Expression Regulation/drug effects MH - Male MH - Nuclear Receptor Coactivators/genetics/metabolism MH - Organ Specificity MH - Phenols/*toxicity MH - Pregnancy MH - Prenatal Exposure Delayed Effects/chemically induced/*metabolism MH - Rats, Wistar MH - Testis/metabolism MH - Uterus/metabolism MH - Wnt Proteins/genetics/metabolism OTO - NOTNLM OT - Bisphenol A OT - ESR1 OT - Rat OT - Uterine glands OT - Uterus OT - Wnt EDAT- 2016/02/24 06:00 MHDA- 2016/12/27 06:00 CRDT- 2016/02/23 06:00 PHST- 2015/11/02 00:00 [received] PHST- 2016/02/11 00:00 [revised] PHST- 2016/02/11 00:00 [accepted] PHST- 2016/02/23 06:00 [entrez] PHST- 2016/02/24 06:00 [pubmed] PHST- 2016/12/27 06:00 [medline] AID - S0303-7207(16)30037-5 [pii] AID - 10.1016/j.mce.2016.02.010 [doi] PST - ppublish SO - Mol Cell Endocrinol. 2016 May 5;426:33-42. doi: 10.1016/j.mce.2016.02.010. Epub 2016 Feb 16.