PMID- 26900624
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20181113
IS  - 2164-554X (Electronic)
IS  - 2164-5515 (Print)
IS  - 2164-5515 (Linking)
VI  - 12
IP  - 7
DP  - 2016 Jul 2
TI  - Rabies post-exposure prophylaxis for a child with severe allergic reaction to 
      rabies vaccine.
PG  - 1802-4
LID - 10.1080/21645515.2016.1143158 [doi]
AB  - Most adverse events (AEs) during the immunization of rabies vaccine were slight, 
      there was little information about the allergic reaction induced by rabies 
      vaccines and had to stop or change the immunization program. Here, we reported a 
      case that a 4-year-old boy had category II exposure to rabies and showed severe 
      allergic reaction after being immunized with lyophilized purified vero cell 
      rabies vaccine (PVRV). After the anti-allergy therapy with hormone, allergy 
      testing indicated medium allergy to egg and milk, and implied the allergic 
      reaction most likely associated with animal-sourced gelatin in lyophilized PVRV. 
      Therefore, a new immunization program with liquid PVRV without stabilizers under 
      the Zegrab regimen (2-1-1) was enrolled at day 7 post-exposure. Although lower 
      than the levels of normal <5 -year population at day 14 and 45, the neutralizing 
      antibody (RVNA) titers of this boy showed adequate protective antibody (>/= 
      0.5 IU/ml), even after 365 d post-immunization. This study not only highlighted 
      the importance of several types of rabies vaccines co-existing in the market, but 
      also implied the necessary for doctors to fully understand the allergies history 
      of patients prior to immunize rabies vaccine.
FAU - Fang, Yuan
AU  - Fang Y
AD  - a Department of Neurology , Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology , Wuhan , China.
FAU - Liu, Man-Qing
AU  - Liu MQ
AD  - b Wuhan Centers for Disease Prevention & Control , Wuhan , China.
FAU - Chen, Li
AU  - Chen L
AD  - c Jianghan Center for Disease Prevention and Control , Wuhan , China.
FAU - Zhu, Zheng-Gang
AU  - Zhu ZG
AD  - b Wuhan Centers for Disease Prevention & Control , Wuhan , China.
FAU - Zhu, Ze-Rong
AU  - Zhu ZR
AD  - b Wuhan Centers for Disease Prevention & Control , Wuhan , China.
FAU - Hu, Quan
AU  - Hu Q
AD  - b Wuhan Centers for Disease Prevention & Control , Wuhan , China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160222
PL  - United States
TA  - Hum Vaccin Immunother
JT  - Human vaccines & immunotherapeutics
JID - 101572652
RN  - 0 (Rabies Vaccines)
SB  - IM
MH  - Animals
MH  - Child, Preschool
MH  - Humans
MH  - *Hypersensitivity
MH  - Male
MH  - *Post-Exposure Prophylaxis
MH  - Rabies/*prevention & control
MH  - Rabies Vaccines/*administration & dosage/*adverse effects
PMC - PMC4964825
OTO - NOTNLM
OT  - allergic reaction
OT  - neutralizing antibody (RVNA) titer
OT  - purified chick embryo cell vaccine (PCECV)
OT  - purified vero cell rabies vaccine (PVRV)
OT  - rabies virus neutralizing antibody (RVNA)
EDAT- 2016/02/24 06:00
MHDA- 2017/10/17 06:00
PMCR- 2017/02/22
CRDT- 2016/02/23 06:00
PHST- 2016/02/23 06:00 [entrez]
PHST- 2016/02/24 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2017/02/22 00:00 [pmc-release]
AID - 1143158 [pii]
AID - 10.1080/21645515.2016.1143158 [doi]
PST - ppublish
SO  - Hum Vaccin Immunother. 2016 Jul 2;12(7):1802-4. doi: 
      10.1080/21645515.2016.1143158. Epub 2016 Feb 22.