PMID- 26901241 OWN - NLM STAT- MEDLINE DCOM- 20161219 LR - 20210109 IS - 1750-2659 (Electronic) IS - 1750-2640 (Print) IS - 1750-2640 (Linking) VI - 10 IP - 3 DP - 2016 May TI - Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C-159T polymorphisms with the risk of severe RSV infection: a meta-analysis. PG - 224-33 LID - 10.1111/irv.12378 [doi] AB - Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization in infants worldwide. It is recognized by Toll-like receptor 4 (TLR 4) and cluster of differentiation 14 (CD14) in the innate immune response. Previous case-control studies reported the influence of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C-159T polymorphisms on the risk of severe RSV infection. However, a decisive conclusion has not been achieved. Therefore, we performed this meta-analysis to examine the association between these three polymorphisms and the development of RSV bronchiolitis. A systematic literature search was performed using the PubMed, EMbase, Google Scholar Search, China National Knowledge Infrastructure, China Biological Medicine, and Wanfang Databases. The data were extracted and pooled odds ratios with 95% confidence intervals were calculated under six genetic models. A total of six studies with 1009 cases and 1348 controls, three studies with 473 cases and 481 controls, or four studies with 325 cases and 650 controls relating to each of the three polymorphisms were included in this meta-analysis. The analyzed data indicated that all of these polymorphisms were not associated with the risk of severe RSV infection. This is the first meta-analysis to investigate the relationship of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C-159T polymorphisms with the risk of severe RSV infection. Although the results of this retrospective analysis indicated a lack of the association, more extensive multicentric studies with large sample sizes are necessary to provide a more reliable estimation of the association between these three polymorphisms and RSV bronchiolitis susceptibility. CI - (c) 2016 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. FAU - Zhou, Jiahui AU - Zhou J AD - China-America Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China. AD - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong, China. AD - Department of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, China. FAU - Zhang, Xiangning AU - Zhang X AD - China-America Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China. AD - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong, China. AD - Department of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, China. FAU - Liu, Shuming AU - Liu S AD - China-America Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China. AD - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong, China. AD - Department of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, China. FAU - Wang, Ziyou AU - Wang Z AD - China-America Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China. AD - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong, China. AD - Department of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, China. FAU - Chen, Qicong AU - Chen Q AD - School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, China. FAU - Wu, Yongfu AU - Wu Y AD - Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China. FAU - He, Zhiwei AU - He Z AD - China-America Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China. AD - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong, China. AD - Department of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, China. FAU - Huang, Zunnan AU - Huang Z AD - China-America Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China. AD - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong, China. AD - Department of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20160307 PL - England TA - Influenza Other Respir Viruses JT - Influenza and other respiratory viruses JID - 101304007 RN - 0 (Lipopolysaccharide Receptors) RN - 0 (TLR4 protein, human) RN - 0 (Toll-Like Receptor 4) SB - IM MH - Bronchiolitis/genetics/*virology MH - Case-Control Studies MH - China MH - Genetic Association Studies MH - *Genetic Predisposition to Disease MH - Genotype MH - Humans MH - Lipopolysaccharide Receptors/*genetics MH - Odds Ratio MH - *Polymorphism, Single Nucleotide MH - Respiratory Syncytial Virus Infections/*genetics/immunology/virology MH - Retrospective Studies MH - Risk Factors MH - Toll-Like Receptor 4/*genetics PMC - PMC4814857 OTO - NOTNLM OT - Asp299Gly OT - C-159T OT - CD14 OT - RSV infection OT - TLR4 OT - Thr399Ile OT - meta-analysis OT - polymorphisms EDAT- 2016/02/24 06:00 MHDA- 2016/12/20 06:00 PMCR- 2016/05/01 CRDT- 2016/02/23 06:00 PHST- 2016/01/28 00:00 [accepted] PHST- 2016/02/23 06:00 [entrez] PHST- 2016/02/24 06:00 [pubmed] PHST- 2016/12/20 06:00 [medline] PHST- 2016/05/01 00:00 [pmc-release] AID - IRV12378 [pii] AID - 10.1111/irv.12378 [doi] PST - ppublish SO - Influenza Other Respir Viruses. 2016 May;10(3):224-33. doi: 10.1111/irv.12378. Epub 2016 Mar 7.