PMID- 26902177
OWN - NLM
STAT- MEDLINE
DCOM- 20161107
LR  - 20240324
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 22
DP  - 2016 Feb 23
TI  - Dose Evaluation of Fractionated Schema and Distance From Tumor to Spinal Cord for 
      Spinal SBRT with Simultaneous Integrated Boost: A Preliminary Study.
PG  - 598-607
AB  - BACKGROUND This study investigated and quantified the dosimetric impact of the 
      distance from the tumor to the spinal cord and fractionation schemes for patients 
      who received stereotactic body radiation therapy (SBRT) and hypofractionated 
      simultaneous integrated boost (HF-SIB). MATERIAL AND METHODS Six modified 
      planning target volumes (PTVs) for 5 patients with spinal metastases were created 
      by artificial uniform extension in the region of PTV adjacent spinal cord with a 
      specified minimum tumor to cord distance (0-5 mm). The prescription dose 
      (biologic equivalent dose, BED) was 70 Gy in different fractionation schemes (1, 
      3, 5, and 10 fractions). For PTV V100, Dmin, D98, D95, and D1, spinal cord dose, 
      conformity index (CI), V30 were measured and compared. RESULTS PTV-to-cord 
      distance influenced PTV V100, Dmin, D98, and D95, and fractionation schemes 
      influenced Dmin and D98, with a significant difference. Distances of >/=2 mm, >/=1 
      mm, >/=1 mm, and >/=0 mm from PTV to spinal cord meet dose requirements in 1, 3, 5, 
      and 10 fractionations, respectively. Spinal cord dose, CI, and V30 were not 
      impacted by PTV-to-cord distance and fractionation schemes. CONCLUSIONS Target 
      volume coverage, Dmin, D98, and D95 were directly correlated with distance from 
      the spinal cord for spine SBRT and HF-SIB. Based on our study, >/=2 mm, >/=1 mm, >/=1 
      mm, and >/=0 mm distance from PTV to spinal cord meets dose requirements in 1, 3, 5 
      and 10 fractionations, respectively.
FAU - Yang, Hao
AU  - Yang H
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Cai, Bo-ning
AU  - Cai BN
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Wang, Xiao-shen
AU  - Wang XS
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Cong, Xiao-hu
AU  - Cong XH
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Wang, Jin-yuan
AU  - Wang JY
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Oncology, First Affiliated Hospital of Xinxiang Medical University, 
      Weihui, Henan, China (mainland).
FAU - Xu, Shou-ping
AU  - Xu SP
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Ju, Zhong-jian
AU  - Ju ZJ
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
FAU - Ma, Lin
AU  - Ma L
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 
      (mainland).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160223
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - *Dose Fractionation, Radiation
MH  - Humans
MH  - Radiosurgery/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Spinal Cord/*diagnostic imaging/*surgery
MH  - Spinal Cord Neoplasms/*diagnostic imaging/*surgery
PMC - PMC4767138
EDAT- 2016/02/24 06:00
MHDA- 2016/11/08 06:00
PMCR- 2016/02/23
CRDT- 2016/02/24 06:00
PHST- 2016/02/24 06:00 [entrez]
PHST- 2016/02/24 06:00 [pubmed]
PHST- 2016/11/08 06:00 [medline]
PHST- 2016/02/23 00:00 [pmc-release]
AID - 897146 [pii]
AID - 10.12659/msm.897146 [doi]
PST - epublish
SO  - Med Sci Monit. 2016 Feb 23;22:598-607. doi: 10.12659/msm.897146.