PMID- 26902190
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20181202
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 96
IP  - 7
DP  - 2016 Feb 23
TI  - [Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory 
      human temporal lobe epilepsy].
PG  - 522-5
LID - 10.3760/cma.j.issn.0376-2491.2016.07.006 [doi]
AB  - OBJECTIVE: To study apoptosis and expression of Caspase 3 and Caspase 4 in 
      temporal lobe neurocytes of refractory human temporal lobe epilepsy (TLE). 
      METHODS: The temporal tissue samples were obtained from 30 cases of refractory 
      TLE (TLE group) and 10 cases of brain trauma (contrast group) between January 
      1993 and May 2008. The surgical specimens were paraffin-embedded samples from 
      Department of Pathology of Fujian Medical University and Department of 
      Neurosurgery, the First Affiliated Hospital of Fujian Medical University. S-P 
      staining of immunohistochemistry was used to detect the expression of Caspase 3 
      and Caspase 4 in temporal lobe neurocytes of TLE group and contrast group. Their 
      expression was then analyzed. The terminal deoxynucleoitidyl transferase-mediated 
      dUTP nick end labeling (TUNEL) staining was performed to visualize and analyze 
      the neurocytes' apoptosis of two groups. RESULTS: The expression of Caspase 3 and 
      Caspase 4 in neurocytes of TLE group were both higher than that of contrast group 
      (t=12.905, P<0.01; t=11.880, P<0.01). The apoptotic index (AI) of neurocytes in 
      TLE group also increased than that of contrast group (t=9.664, P<0.01). 
      CONCLUSION: Caspase 3 and Caspase 4 may mediate neurocytes apoptosis in temporal 
      lobe tissue of refractory human TLE.
FAU - Lin, R T
AU  - Lin RT
AD  - Department of Neurology, Second Affiliated Hospital, Fujian Medical University, 
      Quanzhou 362000, China.
FAU - Cai, R R
AU  - Cai RR
FAU - Zhang, P F
AU  - Zhang PF
FAU - Lin, Y X
AU  - Lin YX
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - EC 3.4.22.- (CASP3 protein, human)
RN  - EC 3.4.22.- (CASP4 protein, human)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspases, Initiator)
SB  - IM
MH  - Apoptosis
MH  - Caspase 3
MH  - Caspases, Initiator
MH  - *Epilepsy, Temporal Lobe
MH  - Humans
MH  - Immunohistochemistry
MH  - *Neurons
MH  - Temporal Lobe
EDAT- 2016/02/24 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/02/24 06:00
PHST- 2016/02/24 06:00 [entrez]
PHST- 2016/02/24 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2016.07.006 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2016 Feb 23;96(7):522-5. doi: 
      10.3760/cma.j.issn.0376-2491.2016.07.006.