PMID- 26902449
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20221207
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 80
IP  - 4
DP  - 2016
TI  - Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in 
      Japanese Hypertrophic Cardiomyopathy Patients.
PG  - 950-7
LID - 10.1253/circj.CJ-15-1100 [doi]
AB  - BACKGROUND: In addition to the presence of late gadolinium enhancement (LGE) on 
      cardiovascular magnetic resonance (CMR), the extent of LGE is considered 
      clinically important in hypertrophic cardiomyopathy (HCM). We evaluated the 
      extent of LGE on CMR in a large series of Japanese HCM patients. 
      METHODS AND RESULTS: CMR was performed in 317 HCM patients (147 male). The extent 
      of LGE was scored as the sum of LGE-positive segments in a left ventricle (LV) 
      17-segment model. LGE was present in 246 patients (77.6%). LGE was detected in 
      3.5+/-3.1 segments on average. When the patients were divided according to maximum 
      wall thickness (mild, <20 mm; moderate, 20-29 mm; severe, >/=30 mm), median LGE 
      score increased as wall thickness increased (mild, 2 vs. moderate, 4 vs. severe, 
      5; P=0.000). When the patients were divided according to ejection fraction (EF) 
      (reduced, <50%; low-normal, 50-65%; normal, >65%), median LGE score increased as 
      EF decreased (reduced, 7 vs. low-normal, 4 vs. normal, 2; P=0.000). On 
      multivariate analysis, reduced EF (OR, 0.947, P=0.015), pressure gradient <30 
      mmHg (OR, 0.359, P=0.000) and increased maximum wall thickness (OR, 1.236, 
      P=0.000) were independent factors associated with extensive LGE. CONCLUSIONS: 
      Progression of LGE was related to increased wall thickness, decreased 
      contractility, and reduced intraventricular pressure gradient.
FAU - Hen, Yasuki
AU  - Hen Y
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Iguchi, Nobuo
AU  - Iguchi N
FAU - Utanohara, Yuko
AU  - Utanohara Y
FAU - Takada, Kaori
AU  - Takada K
FAU - Machida, Haruhiko
AU  - Machida H
FAU - Takara, Ayako
AU  - Takara A
FAU - Teraoka, Kunihiko
AU  - Teraoka K
FAU - Sumiyoshi, Tetsuya
AU  - Sumiyoshi T
FAU - Takamisawa, Itaru
AU  - Takamisawa I
FAU - Takayama, Morimasa
AU  - Takayama M
FAU - Yoshikawa, Tsutomu
AU  - Yoshikawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160219
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Gadolinium/*administration & dosage
MH  - Humans
MH  - Japan
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2016/02/24 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/24 06:00
PHST- 2016/02/24 06:00 [entrez]
PHST- 2016/02/24 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1253/circj.CJ-15-1100 [doi]
PST - ppublish
SO  - Circ J. 2016;80(4):950-7. doi: 10.1253/circj.CJ-15-1100. Epub 2016 Feb 19.