PMID- 26902557
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20170110
IS  - 1471-1788 (Electronic)
IS  - 1365-1501 (Linking)
VI  - 20
IP  - 2
DP  - 2016
TI  - Insight and recovery in schizophrenic patients.
PG  - 83-90
LID - 10.3109/13651501.2016.1141960 [doi]
AB  - OBJECTIVE: To investigate the correlation between insight and recovery in 
      schizophrenic patients according to criteria for both symptomatic and functional 
      remission. METHODS: Seventy patients affected by paranoid schizophrenia were 
      recruited and treated with olanzapine, risperidone, aripiprazole, haloperidol and 
      ziprasidone; visits were scheduled at baseline, 12 and 36 months. We administered 
      PANSS (Positive and Negative Syndrome Scale), GAF (Global Assessment of 
      Functioning), SF-36 (Short Form 36 Health Survey), PGWBI (Psychological General 
      Well-Being index) and SAI (Schedule for the Assessment of Insight). RESULTS: 
      After 1 year, 50% of the subjects obtained symptom remission and 25.5% had 
      adequate social functioning for 2 years or more. Only 12% of subjects met full 
      recovery criteria for 2 years or longer. The recovery group also showed an 
      improvement in insight levels, especially patients treated with second-generation 
      antipsychotics (SGA). Recovery was predicted by female sex, higher age, SGA 
      treatment, pre-morbid social adaptation and low level of negative symptoms at 
      baseline. CONCLUSIONS: Only a small proportion of schizophrenic patients achieved 
      recovery, therefore greater patient's insight could have prognostic validity in 
      terms of treatment outcome. More sensitive instruments and a larger sample are 
      necessary to confirm these results.
FAU - Cannavo, Dario
AU  - Cannavo D
AD  - a Psychiatry Unit , Department of Clinical and Experimental Medicine - 
      'Policlinico - Vittorio Emanuele' University Hospital of Catania , Catania , 
      Italy.
FAU - Minutolo, Giuseppe
AU  - Minutolo G
AD  - a Psychiatry Unit , Department of Clinical and Experimental Medicine - 
      'Policlinico - Vittorio Emanuele' University Hospital of Catania , Catania , 
      Italy.
FAU - Battaglia, Eliana
AU  - Battaglia E
AD  - a Psychiatry Unit , Department of Clinical and Experimental Medicine - 
      'Policlinico - Vittorio Emanuele' University Hospital of Catania , Catania , 
      Italy.
FAU - Aguglia, Eugenio
AU  - Aguglia E
AD  - a Psychiatry Unit , Department of Clinical and Experimental Medicine - 
      'Policlinico - Vittorio Emanuele' University Hospital of Catania , Catania , 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160223
PL  - England
TA  - Int J Psychiatry Clin Pract
JT  - International journal of psychiatry in clinical practice
JID - 9709509
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antipsychotic Agents/*therapeutic use
MH  - *Comprehension
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Remission Induction
MH  - Schizophrenia/*drug therapy
MH  - *Schizophrenic Psychology
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Antipsychotics
OT  - insight
OT  - recovery
OT  - schizophrenia
EDAT- 2016/02/24 06:00
MHDA- 2017/01/10 06:00
CRDT- 2016/02/24 06:00
PHST- 2016/02/24 06:00 [entrez]
PHST- 2016/02/24 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - 10.3109/13651501.2016.1141960 [doi]
PST - ppublish
SO  - Int J Psychiatry Clin Pract. 2016;20(2):83-90. doi: 
      10.3109/13651501.2016.1141960. Epub 2016 Feb 23.