PMID- 26903238
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20240325
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 42 Suppl 1
IP  - Suppl 1
DP  - 2016 Jul
TI  - Intensive Auditory Cognitive Training Improves Verbal Memory in Adolescents and 
      Young Adults at Clinical High Risk for Psychosis.
PG  - S118-26
LID - 10.1093/schbul/sbw009 [doi]
AB  - OBJECTIVE: Individuals at clinical high risk (CHR) for psychosis demonstrate 
      cognitive impairments that predict later psychotic transition and real-world 
      functioning. Cognitive training has shown benefits in schizophrenia, but has not 
      yet been adequately tested in the CHR population. METHODS: In this double-blind 
      randomized controlled trial, CHR individuals (N = 83) were given laptop computers 
      and trained at home on 40 hours of auditory processing-based exercises designed 
      to target verbal learning and memory operations, or on computer games (CG). 
      Participants were assessed with neurocognitive tests based on the Measurement and 
      Treatment Research to Improve Cognition in Schizophrenia initiative (MATRICS) 
      battery and rated on symptoms and functioning. Groups were compared before and 
      after training using a mixed-effects model with restricted maximum likelihood 
      estimation, given the high study attrition rate (42%). RESULTS: Participants in 
      the targeted cognitive training group showed a significant improvement in Verbal 
      Memory compared to CG participants (effect size = 0.61). Positive and Total 
      symptoms improved in both groups over time. CONCLUSIONS: CHR individuals showed 
      patterns of training-induced cognitive improvement in verbal memory consistent 
      with prior observations in schizophrenia. This is a particularly vulnerable 
      domain in individuals at-risk for psychosis that predicts later functioning and 
      psychotic transition. Ongoing follow-up of this cohort will assess the durability 
      of training effects in CHR individuals, as well as the potential impact on 
      symptoms and functioning over time. Clinical Trials Number: NCT00655239. URL: 
      https://clinicaltrials.gov/ct2/show/NCT00655239?term=vinogradov&rank=5.
CI  - Published by Oxford University Press on behalf of the Maryland Psychiatric 
      Research Center 2016.
FAU - Loewy, Rachel
AU  - Loewy R
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      CA;
FAU - Fisher, Melissa
AU  - Fisher M
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      CA; Department of Psychiatry, San Francisco Department of Veterans Affairs 
      Medical Center, San Francisco, CA.
FAU - Schlosser, Danielle A
AU  - Schlosser DA
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      CA;
FAU - Biagianti, Bruno
AU  - Biagianti B
AD  - Department of Psychiatry, San Francisco Department of Veterans Affairs Medical 
      Center, San Francisco, CA.
FAU - Stuart, Barbara
AU  - Stuart B
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      CA;
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      CA; Department of Psychiatry, San Francisco Department of Veterans Affairs 
      Medical Center, San Francisco, CA.
FAU - Vinogradov, Sophia
AU  - Vinogradov S
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      CA; Department of Psychiatry, San Francisco Department of Veterans Affairs 
      Medical Center, San Francisco, CA Sophia.vinogradov@ucsf.edu.
LA  - eng
SI  - ClinicalTrials.gov/NCT00655239
GR  - K23 MH097795/MH/NIMH NIH HHS/United States
GR  - R01 MH081051/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160222
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Auditory Perception/*physiology
MH  - Child
MH  - Cognitive Dysfunction/etiology/physiopathology/*rehabilitation
MH  - Cognitive Remediation/*methods
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory/*physiology
MH  - *Outcome Assessment, Health Care
MH  - Psychotic Disorders/*complications
MH  - Schizophrenia/*complications
MH  - Verbal Learning/*physiology
MH  - Young Adult
PMC - PMC4960436
OTO - NOTNLM
OT  - cognitive remediation
OT  - prodrome
OT  - schizophrenia
EDAT- 2016/02/24 06:00
MHDA- 2017/07/01 06:00
PMCR- 2017/07/01
CRDT- 2016/02/24 06:00
PHST- 2016/02/24 06:00 [entrez]
PHST- 2016/02/24 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - sbw009 [pii]
AID - 10.1093/schbul/sbw009 [doi]
PST - ppublish
SO  - Schizophr Bull. 2016 Jul;42 Suppl 1(Suppl 1):S118-26. doi: 10.1093/schbul/sbw009. 
      Epub 2016 Feb 22.