PMID- 26905038 OWN - NLM STAT- MEDLINE DCOM- 20161227 LR - 20210130 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 172 IP - 1-3 DP - 2016 Apr TI - The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis. PG - 29-34 LID - S0920-9964(16)30058-5 [pii] LID - 10.1016/j.schres.2016.02.002 [doi] AB - BACKGROUND: Prodromal syndromes often begin in adolescence - a period of neurodevelopmental changes and heightened stress sensitivity. Research has shown elevated stress and cortisol in individuals at clinical high risk (CHR) for psychosis. This cross-sectional study examined relations of age and pubertal status with cortisol and self-reported stress in healthy controls (HCs) and CHR adolescents. It was hypothesized that the relations of age and pubertal stage with cortisol and stress would be more pronounced in CHR youth. METHODS: Participants were 93 HCs and 348 CHR adolescents from the North American Prodrome Longitudinal Study (NAPLS). At baseline, measures of stress (Daily Stress Inventory - DSI), Tanner stage (TS), and salivary cortisol were obtained. RESULTS: ANCOVA revealed increased DSI scores with age for both groups, and higher DSI scores in CHR adolescents than HCs, with a more pronounced difference for females. Contrary to prediction, with age controlled, HCs showed greater TS-related DSI increases. Analysis of cortisol showed no significant interactions, but a main effect of age and a trend toward higher cortisol in the CHR group. Correlations of cortisol with TS were higher in HC than CHR group. CONCLUSIONS: Stress measures increased with age in HC and CHR adolescents, and DSI scores also increased with TS in HCs. The results do not support a more pronounced age or TS increase in stress measures in CHR adolescents, but instead suggest that stress indices tend to be elevated earlier in adolescence in the CHR group. Potential determinants of findings and future directions are discussed. CI - Copyright (c) 2016 Elsevier B.V. All rights reserved. FAU - Moskow, Danielle M AU - Moskow DM AD - Emory University, 36 Eagle Row, Atlanta, GA 30322, USA. Electronic address: dmoskow@nyspi.columbia.edu. FAU - Addington, Jean AU - Addington J AD - University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada. Electronic address: jmadding@ucalgary.ca. FAU - Bearden, Carrie E AU - Bearden CE AD - Univeristy of California, 300 Medical Plaza Suite 2265, Los Angeles, CA 90095, USA. Electronic address: cbearden@mednet.ucla.edu. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - University of California, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: kcadenhead@ucsd.edu. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Zucker Hillside Hospital, Glen Oaks, NY 11004, USA. Electronic address: cornblat@lij.edu. FAU - Heinssen, Robert AU - Heinssen R AD - National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20893, USA. Electronic address: rheinsse@mail.nih.gov. FAU - Mathalon, Daniel H AU - Mathalon DH AD - University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA. Electronic address: Daniel.Mathalon@ucsf.edu. FAU - McGlashan, Thomas H AU - McGlashan TH AD - Yale University, 300 George Street, New Haven, CT 06511, USA. Electronic address: thomas.mcglashan@yale.edu. FAU - Perkins, Diana O AU - Perkins DO AD - University of North Carolina, 101 Manning Dr, Chapel Hill, NC 27514, USA. Electronic address: diana_perkins@med.unc.edu. FAU - Seidman, Larry J AU - Seidman LJ AD - Harvard University, 55 Friot Street, Boston, MA 02114, USA. Electronic address: lseidman@caregroup.harvard.edu. FAU - Tsuang, Ming T AU - Tsuang MT AD - University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. Electronic address: mtsuang@ucsd.edu. FAU - Cannon, Tyrone D AU - Cannon TD AD - Yale University, 1 Prospect Street, New Haven, CT 06511, USA. Electronic address: tyrone.cannon@yale.edu. FAU - Woods, Scott W AU - Woods SW AD - Yale University, 300 George Street, New Haven, CT 06511, USA. Electronic address: scott.woods@yale.edu. FAU - Walker, Elaine F AU - Walker EF AD - Emory University, 36 Eagle Row, Atlanta, GA 30322, USA. Electronic address: psyefw@emory.edu. LA - eng GR - P51 OD011132/OD/NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - U01 MH081988/MH/NIMH NIH HHS/United States GR - P50 MH066286/MH/NIMH NIH HHS/United States GR - U01 MH076989/MH/NIMH NIH HHS/United States GR - U01 MH066160/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - U01 MH081857/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States GR - U01 MH081944/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20160220 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Adolescent MH - Female MH - Humans MH - Hydrocortisone/*metabolism MH - Longitudinal Studies MH - Male MH - Prodromal Symptoms MH - Psychotic Disorders/epidemiology/*physiopathology MH - Puberty/*physiology MH - Risk MH - Saliva/*metabolism MH - Schizophrenia/epidemiology/*physiopathology MH - Sex Characteristics MH - Stress, Psychological/epidemiology/*physiopathology PMC - PMC4821739 MID - NIHMS762149 OTO - NOTNLM OT - Clinical high risk OT - Cortisol OT - Psychosis OT - Puberty OT - Schizophrenia OT - Stress COIS- Author Disclosure Conflict of Interest All other authors declare that they have no conflict of interest. EDAT- 2016/02/26 06:00 MHDA- 2016/12/28 06:00 PMCR- 2017/04/01 CRDT- 2016/02/25 06:00 PHST- 2015/11/06 00:00 [received] PHST- 2016/01/28 00:00 [revised] PHST- 2016/02/01 00:00 [accepted] PHST- 2016/02/25 06:00 [entrez] PHST- 2016/02/26 06:00 [pubmed] PHST- 2016/12/28 06:00 [medline] PHST- 2017/04/01 00:00 [pmc-release] AID - S0920-9964(16)30058-5 [pii] AID - 10.1016/j.schres.2016.02.002 [doi] PST - ppublish SO - Schizophr Res. 2016 Apr;172(1-3):29-34. doi: 10.1016/j.schres.2016.02.002. Epub 2016 Feb 20.