PMID- 26905044
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20191210
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Print)
IS  - 1064-7481 (Linking)
VI  - 24
IP  - 4
DP  - 2016 Apr
TI  - "Engage" Therapy: Behavioral Activation and Improvement of Late-Life Major 
      Depression.
PG  - 320-6
LID - S1064-7481(15)00296-1 [pii]
LID - 10.1016/j.jagp.2015.11.006 [doi]
AB  - OBJECTIVE: Engage is a treatment for late-life depression developed to match the 
      skills of community clinicians based on the theory that dysfunction in the 
      Research Domain Criteria Project positive valence systems is a critical mechanism 
      of late-life depression. Accordingly, it uses "reward exposure" (engagement in 
      meaningful, rewarding activities) as its principal intervention. This study tests 
      the hypothesis that change in behavioral activation, an index of positive valence 
      systems function, during successive treatment periods with Engage and during 
      follow-up predicts depression at the end of each period. METHODS: Forty-eight 
      nondemented, older adults with unipolar major depression were treated openly with 
      9 weekly sessions of Engage and assessed 36 weeks after entry. Depression 
      severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) 
      and behavioral activation with the Behavioral Activation for Depression Scale 
      (BADS) at baseline, 6 weeks (mid-treatment), 9 weeks (end of treatment), and 36 
      weeks. RESULTS: A mixed-effects model examined whether change in BADS in 
      successive periods occurring during Engage treatment and during follow-up 
      predicts depression at the end of each period. Both BADS change (F1,52 = 18.63, 
      p < 0.0001) and time (F2,52 = 7.68, p = 0.0012) predicted HAM-D scores at the end 
      of each observation period. Every point of increase in BADS change reduced the 
      HAM-D by 0.105 points. HAM-D at each point did not predict subsequent change in 
      BADS (F1,52 = 2.17, p = 0.146). CONCLUSION: During Engage treatment and 
      follow-up, change in behavioral activation is followed by improvement of 
      depressive symptoms and signs.
CI  - Copyright (c) 2016 American Association for Geriatric Psychiatry. Published by 
      Elsevier Inc. All rights reserved.
FAU - Alexopoulos, George S
AU  - Alexopoulos GS
AD  - Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA. 
      Electronic address: gsalexop@med.cornell.edu.
FAU - Raue, Patrick J
AU  - Raue PJ
AD  - Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA.
FAU - Gunning, Faith
AU  - Gunning F
AD  - Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA.
FAU - Kiosses, Dimitris N
AU  - Kiosses DN
AD  - Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA.
FAU - Kanellopoulos, Dora
AU  - Kanellopoulos D
AD  - Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA.
FAU - Pollari, Cristina
AU  - Pollari C
AD  - Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA.
FAU - Banerjee, Samprit
AU  - Banerjee S
AD  - Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA.
FAU - Arean, Patricia A
AU  - Arean PA
AD  - Department of Psychiatry and Behavioral Sciences (PAA), University of Washington, 
      Seattle, WA, USA.
LA  - eng
GR  - P30 MH085943/MH/NIMH NIH HHS/United States
GR  - R01 MH075900/MH/NIMH NIH HHS/United States
GR  - R01 MH064099/MH/NIMH NIH HHS/United States
GR  - K24 MH074717/MH/NIMH NIH HHS/United States
GR  - R01 MH102252/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151217
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Behavior Therapy/*methods
MH  - Depressive Disorder, Major/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Outcome Assessment, Health Care/*methods
MH  - *Reward
PMC - PMC4818673
MID - NIHMS745585
OTO - NOTNLM
OT  - Engage
OT  - behavioral activation
OT  - treatment of "late-life" depression
EDAT- 2016/02/26 06:00
MHDA- 2017/01/04 06:00
PMCR- 2017/04/01
CRDT- 2016/02/25 06:00
PHST- 2015/09/24 00:00 [received]
PHST- 2015/11/09 00:00 [revised]
PHST- 2015/11/09 00:00 [accepted]
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - S1064-7481(15)00296-1 [pii]
AID - 10.1016/j.jagp.2015.11.006 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2016 Apr;24(4):320-6. doi: 10.1016/j.jagp.2015.11.006. 
      Epub 2015 Dec 17.