PMID- 26905348
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20240325
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 37
IP  - 3
DP  - 2016 Mar
TI  - Diagnostic efficacy of random albumin creatinine ratio for detection of micro and 
      macro-albuminuria in type 2 diabetes mellitus.
PG  - 268-73
LID - 10.15537/smj.2016.3.13567 [doi]
AB  - OBJECTIVES: To compare a less cumbersome random albumin creatinine ratio (RACR) 
      with 24-hour urinary albumin excretion (UAE) for detection of renal damage in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: This retrospective study 
      performed between March 2013 and June 2014 at the Department of Pathology, King 
      Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia included 122 patients 
      (mean age 54 +/- 15, 104 females and 18 males) with T2DM. Urine albumin levels of 
      less than 30 mg/g was considered normal, from 30-300 mg/g considered as 
      micro-albuminuria, and over 300 mg/g considered as macro-albuminuria. RESULTS: 
      Concordance between the 2 assays was observed in 114 (93.4%) samples. The 
      sensitivity of RACR assay was 100%, specificity was 91.3% with a positive 
      predictive value (PPV) of 95%, and a negative predictive value (NPV) of 100% in 
      micro-albuminuria range. For macro-albuminuria, RACR had a sensitivity of 100%, 
      specificity of 94.1% with PPV of 94% and NPV of 100%. Receiver operating 
      characteristic (ROC) curves analysis cut-off values of 40 mg/g-300 mg/g for 
      micro- and greater than 300 mg/g for macro-albuminuria revealed 100% sensitivity, 
      97.5% specificity, 95% PPV, and 100% NPV for micro-albuminuria, and 100% 
      sensitivity, 94% specificity, 76% PPV, and 100% NPP for macro-albuminuria. The 
      area under the curve for micro-albuminuria was 100% and 98.2% for 
      macro-albuminuria. CONCLUSION: Performance of RACR was comparable to 24 hour UAE 
      assay particularly in excluding renal damage in T2DM.
FAU - Hasanato, Rana M
AU  - Hasanato RM
AD  - Department of Pathology, College of Medicine and University Hospitals, King Saud 
      University, Riyadh, Kingdom of Saudi Arabia. E-mail. ranamomen@yahoo.com.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/diagnosis/etiology/*urine
MH  - Creatinine/*urine
MH  - Diabetes Mellitus, Type 2/complications/*urine
MH  - Diabetic Nephropathies/diagnosis/etiology/*urine
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Urinalysis
MH  - Urine Specimen Collection/*methods
PMC - PMC4800890
EDAT- 2016/02/26 06:00
MHDA- 2017/01/18 06:00
PMCR- 2016/03/01
CRDT- 2016/02/25 06:00
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - SaudiMedJ-37-268 [pii]
AID - 10.15537/smj.2016.3.13567 [doi]
PST - ppublish
SO  - Saudi Med J. 2016 Mar;37(3):268-73. doi: 10.15537/smj.2016.3.13567.