PMID- 26906148
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1932-751X (Electronic)
IS  - 1932-7501 (Linking)
VI  - 36
IP  - 2
DP  - 2016 Mar-Apr
TI  - Long-Term Exercise Training in Patients With Advanced Chronic Heart Failure: 
      SUSTAINED BENEFITS ON LEFT VENTRICULAR PERFORMANCE AND EXERCISE CAPACITY.
PG  - 117-24
LID - 10.1097/HCR.0000000000000165 [doi]
AB  - PURPOSE: In moderately impaired, stable chronic heart failure (CHF) patients, 
      exercise training (ET) enhances exercise capacity. In contrast, the therapeutic 
      benefits of regular ET in patients with advanced CHF, especially in the 
      long-term, are limited or conflicting. Therefore, the aim of the present 
      investigation was to elucidate whether ET performed over 12 months would improve 
      left ventricular performance and exercise capacity in patients with advanced CHF. 
      METHODS: Thirty-seven patients with CHF and New York Heart Association (NYHA) 
      class IIIb were randomized to a sedentary lifestyle or daily ET on a cycle 
      ergometer (in-hospital and home-based at 50%-60% of maximal exercise capacity). 
      Cardiopulmonary exercise testing and echocardiography were performed at baseline, 
      3, 6, and 12 months. RESULTS: Exercise training resulted in continuous decreases 
      in left ventricular end-diastolic diameter at 3, 6, and 12 months versus baseline 
      (all P < .05). This was accompanied by a significant increase in resting left 
      ventricular ejection fraction from 24.1% +/- 1.2% at baseline to 38.4% +/- 2.0% at 
      12-month followup (P < .05). Moreover, ET patients increased exercise capacity 
      measured by maximal oxygen uptake (Equation is included in full-text 
      article.)O2max at 3, 6, and 12 months compared with baseline: 15.3 +/- 0.8 
      mL/min/kg, 17.8 +/- 0.8 mL/min/kg, 19.0 +/- 0.7 mL/min/kg, and 19.5 +/- 0.9 mL/min/kg, 
      respectively (all P < .05 vs baseline). This was associated with a reduced NYHA 
      classification. CONCLUSIONS: Exercise training over 12 months resulted in an 
      improvement in exercise capacity and reversing of left ventricular remodeling in 
      patients with advanced CHF (NYHA IIIb). These beneficial adaptations continued to 
      improve up to 6 months and remained stable thereafter.
FAU - Hollriegel, Robert
AU  - Hollriegel R
AD  - Department of Internal Medicine/Cardiology (Drs Hollriegel, Winzer, Linke, Adams, 
      Mangner, Sandri, Bowen, Schuler, and Erbs), University of Leipzig-Heart Center, 
      Leipzig, Germany; and Heart Center Bremen (Dr Hambrecht), Klinikum Links der 
      Weser, Bremen, Germany.
FAU - Winzer, Ephraim B
AU  - Winzer EB
FAU - Linke, Axel
AU  - Linke A
FAU - Adams, Volker
AU  - Adams V
FAU - Mangner, Norman
AU  - Mangner N
FAU - Sandri, Marcus
AU  - Sandri M
FAU - Bowen, T Scott
AU  - Bowen TS
FAU - Hambrecht, Rainer
AU  - Hambrecht R
FAU - Schuler, Gerhard
AU  - Schuler G
FAU - Erbs, Sandra
AU  - Erbs S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiopulm Rehabil Prev
JT  - Journal of cardiopulmonary rehabilitation and prevention
JID - 101291247
SB  - IM
MH  - Echocardiography/methods
MH  - Exercise Test/methods
MH  - Exercise Therapy/*methods
MH  - *Exercise Tolerance
MH  - Female
MH  - *Heart Failure/diagnosis/physiopathology/psychology/rehabilitation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic/methods
MH  - Sedentary Behavior
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2016/02/26 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/25 06:00
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 01273116-201603000-00006 [pii]
AID - 10.1097/HCR.0000000000000165 [doi]
PST - ppublish
SO  - J Cardiopulm Rehabil Prev. 2016 Mar-Apr;36(2):117-24. doi: 
      10.1097/HCR.0000000000000165.