PMID- 26907482
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20181202
IS  - 2233-6869 (Electronic)
IS  - 1598-9992 (Linking)
VI  - 67
IP  - 2
DP  - 2016 Feb
TI  - [Comparison on Oral versus Intravenous Proton Pump Inhibitors for Prevention of 
      Bleeding after Endoscopic Submucosal Dissection of Gastric Lesions].
PG  - 74-80
LID - 10.4166/kjg.2016.67.2.74 [doi]
AB  - BACKGROUND/AIMS: Although intravenous proton pump inhibitor (PPI) has been used 
      for the prevention of post endoscopic submucosal dissection (ESD) bleeding, the 
      route of administration has not been confirmed. The aim of the present study was 
      to compare the efficacy of intravenous and oral PPI administration for the 
      prevention of delayed post ESD bleeding. METHODS: Total 166 consecutive patients 
      were randomly assigned to 30 mg lansoprazol twice a day (PO group) and 120 mg 
      pantoprazole intravenous injection (IV group) for 48 hours. Finally, 65 patients 
      in PO group and 87 patients in IV group were analyzed. After ESD, all patients 
      underwent follow up endoscopy after 24 hours and were observed the symptoms of 
      bleeding up to 60 days after ESD. RESULTS: Age, sex and use of anticoagulants 
      were not different between groups. At follow up endoscopy after 24 hours, oozing 
      and exposed vessel was noted in 4.6% of PO group and 8.0% of IV group and there 
      was no significant difference. Delayed bleeding occurred in 4 of 65 patients 
      (6.2%) in the PO group and 8 of 87 patients (9.2%) in the IV group (p>0.999). By 
      multivariate analysis, oozing or exposed vessels at follow up endoscopy were risk 
      factors for delayed bleeding (OR=17.5, p=0.022). CONCLUSIONS: There was no 
      significant difference in the delayed bleeding, length of hospital stay according 
      to the administration route. Bleeding stigmata at follow up endoscopy was risk 
      factor of delayed bleeding. Oral PPI administration can cost-effectively replace 
      IV PPI for prevention of post ESD bleeding.
FAU - Jung, Yeoun Su
AU  - Jung YS
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Kim, Kyeong Ok
AU  - Kim KO
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Lee, Si Hyung
AU  - Lee SH
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Jang, Byung Ik
AU  - Jang BI
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Kim, Tae Nyeun
AU  - Kim TN
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
LA  - kor
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anticoagulants)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - D8TST4O562 (Pantoprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use
MH  - *Administration, Oral
MH  - Aged
MH  - Anticoagulants/therapeutic use
MH  - Endoscopic Mucosal Resection/*adverse effects
MH  - Female
MH  - Gastroscopy
MH  - Humans
MH  - *Injections, Intravenous
MH  - Lansoprazole/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pantoprazole
MH  - Postoperative Hemorrhage/etiology/*prevention & control
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Risk Factors
MH  - Stomach Neoplasms/surgery
OTO - NOTNLM
OT  - Endoscopic submucosal dissection
OT  - Hemorrhage
OT  - Proton pump inhibitors
EDAT- 2016/02/26 06:00
MHDA- 2017/01/10 06:00
CRDT- 2016/02/25 06:00
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - 10.4166kjg.2016.67.2.74 [pii]
AID - 10.4166/kjg.2016.67.2.74 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2016 Feb;67(2):74-80. doi: 10.4166/kjg.2016.67.2.74.