PMID- 26907696
OWN - NLM
STAT- MEDLINE
DCOM- 20170711
LR  - 20171116
IS  - 1941-2703 (Electronic)
IS  - 1941-2711 (Linking)
VI  - 29
IP  - 3
DP  - 2016 Jun
TI  - Predicted Deposition of E-Cigarette Aerosol in the Human Lungs.
PG  - 299-309
LID - 10.1089/jamp.2015.1268 [doi]
AB  - BACKGROUND: Health effects of inhaling aerosol produced by electronic cigarettes 
      (ECs) are still uncertain. This work analyzes ECs as specific inhalation devices, 
      which can be characterized by aerodynamic resistance, size distribution of 
      released droplets, and predicted regional and total lung deposition as a function 
      of inhalation maneuver. METHODS: The internal resistance of two types of EC and a 
      conventional cigarette was evaluated by measuring DeltaP-Q curves. Particle size 
      distribution in EC-emitted mist was determined by laser diffraction. The measured 
      data were used to calculate lung deposition based on two approaches: multipath 
      particle dosimetry model (MPPD) and Finlay-Martin correlations. Computations were 
      done for the set of ventilation parameters of an EC user, and also for a 
      by-stander. RESULTS: Tested ECs had higher aerodynamic resistance (1.6-1.9 
      mbar(0.5) min/L) than tobacco cigarette (0.56 mbar(0.5) min/L), and these values 
      are much above the high-resistant DPIs. The average mass median diameter of 
      droplets emitted from ECs was 410 nm, with the average GSD = 1.6. Predicted total 
      lung deposition of the mainstream aerosol was 15%-45% depending on the breathing 
      scheme. An expected increase of particle size in the exhaled aerosol led to 
      predictions of 15%-30% deposition efficiency during passive vaping. CONCLUSIONS: 
      ECs are characterized by high inhalatory resistance, so they require stronger 
      physical effort to transfer cloud of droplets to the lungs, as compared, for 
      example, to DPIs. A significant amount of aerosol is then exhaled, forming an 
      unintentional source of particles to which by-standers are exposed. From this 
      perspective, ECs are not optimal personal aerosol delivery devices.
FAU - Sosnowski, Tomasz R
AU  - Sosnowski TR
AD  - Faculty of Chemical and Process Engineering, Warsaw University of Technology , 
      Warsaw, Poland .
FAU - Kramek-Romanowska, Katarzyna
AU  - Kramek-Romanowska K
AD  - Faculty of Chemical and Process Engineering, Warsaw University of Technology , 
      Warsaw, Poland .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160223
PL  - United States
TA  - J Aerosol Med Pulm Drug Deliv
JT  - Journal of aerosol medicine and pulmonary drug delivery
JID - 101475057
RN  - 0 (Aerosols)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (Smoke)
RN  - 6M3C89ZY6R (Nicotine)
MH  - Administration, Inhalation
MH  - Aerosols
MH  - Computer Simulation
MH  - *Electronic Nicotine Delivery Systems/adverse effects
MH  - Environmental Exposure/adverse effects
MH  - Equipment Design
MH  - Exhalation
MH  - Humans
MH  - Inhalation
MH  - Lung/anatomy & histology/*metabolism
MH  - *Models, Biological
MH  - Nicotine/*administration & dosage/adverse effects
MH  - Nicotinic Agonists/*administration & dosage/adverse effects
MH  - Particle Size
MH  - Pressure
MH  - Smoke
MH  - Smoking/adverse effects/*metabolism
MH  - Tissue Distribution
OTO - NOTNLM
OT  - deposition modeling
OT  - e-cigarette
OT  - inhaler characteristics
OT  - particle size distribution
EDAT- 2016/02/26 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/02/25 06:00
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
AID - 10.1089/jamp.2015.1268 [doi]
PST - ppublish
SO  - J Aerosol Med Pulm Drug Deliv. 2016 Jun;29(3):299-309. doi: 
      10.1089/jamp.2015.1268. Epub 2016 Feb 23.