PMID- 26907971
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20170214
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 10
IP  - 2 Suppl 1
DP  - 2016 Apr-Jun
TI  - Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review.
PG  - S144-9
LID - S1871-4021(15)30070-9 [pii]
LID - 10.1016/j.dsx.2016.01.021 [doi]
AB  - Epidemiological studies have proved that, there are pathophysiological 
      connections between Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). 
      Diabetic patients have higher incidences of cognitive impairment and hence they 
      are more at the risk of developing AD. Some of the recent evidences have majorly 
      stated the effects of insulin resistance in the disturbance of various biological 
      processes and signaling pathways. Both hyperglycemia and hypoglycemic conditions 
      contributes in dysfunctioning of cognitive abilities and functions. The present 
      review summarizes the evidences which establish the possible links between the 
      two pathologies on the account of molecular, biochemical and at histopathological 
      level. The information regarding their interactions was collected from different 
      databases and journals. The gathered information will clearly establish the link 
      among the two pathologies and will be helpful in future for the development of 
      drugs for Type 3 Diabetes.
CI  - Copyright (c) 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Mittal, Khyati
AU  - Mittal K
AD  - Proteomics and Translational Research Lab, Centre for Medical Biotechnology, 
      Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.
FAU - Katare, Deepshikha Pande
AU  - Katare DP
AD  - Proteomics and Translational Research Lab, Centre for Medical Biotechnology, 
      Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India. 
      Electronic address: dpkatare@amity.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160211
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
SB  - IM
MH  - Alzheimer Disease/*complications/metabolism/physiopathology
MH  - Diabetes Mellitus, Type 2/*complications/metabolism/physiopathology
MH  - Humans
MH  - Insulin Resistance
MH  - Models, Molecular
MH  - Oxidative Stress
MH  - Signal Transduction
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Shared links
OT  - Type 2 diabetes mellitus
OT  - Type 3 diabetes
EDAT- 2016/02/26 06:00
MHDA- 2017/02/15 06:00
CRDT- 2016/02/25 06:00
PHST- 2015/11/03 00:00 [received]
PHST- 2016/01/09 00:00 [accepted]
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
AID - S1871-4021(15)30070-9 [pii]
AID - 10.1016/j.dsx.2016.01.021 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S144-9. doi: 
      10.1016/j.dsx.2016.01.021. Epub 2016 Feb 11.