PMID- 26908179
OWN - NLM
STAT- MEDLINE
DCOM- 20171208
LR  - 20191210
IS  - 1873-7714 (Electronic)
IS  - 0163-8343 (Linking)
VI  - 40
DP  - 2016 May-Jun
TI  - Psychiatric referral and glycemic control of Egyptian type 2 diabetes mellitus 
      patients with depression.
PG  - 60-7
LID - S0163-8343(16)00003-7 [pii]
LID - 10.1016/j.genhosppsych.2016.01.002 [doi]
AB  - OBJECTIVE: To evaluate the relationship between psychiatric referral acceptance 
      for fluoxetine treatment and glycemic control in type 2 diabetes mellitus (T2DM) 
      Egyptian patients with depression. METHODS: Patients with T2DM who attended the 
      diabetes outpatients clinic at Zagazig University Hospital, Egypt, between May 
      2013 and April 2015 and who scored >/=20 on screening with the Major Depression 
      Inventory (MDI) (n=196) were offered a psychiatric referral for fluoxetine 
      treatment and monitoring. Decliners (56.1%) received time/attention matched care 
      via diabetologist visits (attentional controls). Fluoxetine patients and controls 
      were compared at the time of the offer (T1) and 8weeks later (T2). Factors that 
      significantly correlated with glycemic control were used in a linear regression 
      analysis as the independent variables. RESULTS: Eighty-six patients (43.9%) 
      accepted psychiatric referral. Most of them (97.7%) remained throughout the study 
      adherent to fluoxetine (mean daily dose=31.9mg). At T2, these patients, in 
      comparison to controls, showed a reduction from baseline in MDI, fasting plasma 
      glucose and glycosylated hemoglobin (HbA1c) levels (P for all comparisons <.001). 
      In the final model of a regression analysis, 65.9% of the variation in percentage 
      change in HbA1c was explained by adherence to antidiabetics, psychiatric referral 
      acceptance and Internalized Stigma of Mental Illness (ISMI) and MDI scores. 
      CONCLUSION: In T2DM patients with depression, psychiatric referral acceptance for 
      fluoxetine treatment is a significant predictor of both depression and glycemic 
      control improvements.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Fawzi, Mounir H
AU  - Fawzi MH
AD  - Department of Psychiatry, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt. Electronic address: mounir.fawzi40@gmail.com.
FAU - Said, Nagwa S
AU  - Said NS
AD  - Department of Internal Medicine, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
FAU - Fawzi, Maggie M
AU  - Fawzi MM
AD  - Department of Clinical Pathology, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
FAU - Kira, Ibrahim A
AU  - Kira IA
AD  - Center for Cumulative Trauma Studies, Stone Mountain, GA, USA.
FAU - Fawzi, Mohab M
AU  - Fawzi MM
AD  - Department of Psychiatry, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Abdel-Moety, Hanaa
AU  - Abdel-Moety H
AD  - Department of Clinical Pathology, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20160114
PL  - United States
TA  - Gen Hosp Psychiatry
JT  - General hospital psychiatry
JID - 7905527
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 01K63SUP8D (Fluoxetine)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents, Second-Generation/administration & dosage/*pharmacology
MH  - Blood Glucose/analysis
MH  - *Depressive Disorder, Major/diagnosis/drug therapy/psychology
MH  - *Diabetes Mellitus, Type 2/blood/drug therapy/psychology
MH  - Egypt
MH  - Female
MH  - Fluoxetine/administration & dosage/*pharmacology
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Male
MH  - Medication Adherence/*statistics & numerical data
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/*statistics & numerical data
MH  - Patient Acceptance of Health Care/*statistics & numerical data
MH  - Prospective Studies
MH  - Referral and Consultation/*statistics & numerical data
MH  - *Social Stigma
OTO - NOTNLM
OT  - Depression
OT  - Diabetes
OT  - Egypt
OT  - Referral
OT  - Stigma
EDAT- 2016/02/26 06:00
MHDA- 2017/12/09 06:00
CRDT- 2016/02/25 06:00
PHST- 2015/06/26 00:00 [received]
PHST- 2016/01/04 00:00 [revised]
PHST- 2016/01/11 00:00 [accepted]
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/12/09 06:00 [medline]
AID - S0163-8343(16)00003-7 [pii]
AID - 10.1016/j.genhosppsych.2016.01.002 [doi]
PST - ppublish
SO  - Gen Hosp Psychiatry. 2016 May-Jun;40:60-7. doi: 
      10.1016/j.genhosppsych.2016.01.002. Epub 2016 Jan 14.