PMID- 26908926
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20181113
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 42
IP  - 4
DP  - 2016 Jul
TI  - Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic 
      Disorders.
PG  - 1056-67
LID - 10.1093/schbul/sbw012 [doi]
AB  - Distracting emotional information impairs attention more in schizophrenia (SCZ) 
      than in never-psychotic individuals. However, it is unclear whether this 
      impairment and its neural circuitry is indicative generally of psychosis, or 
      specifically of SCZ, and whether it is even more specific to certain SCZ symptoms 
      (eg, deficit syndrome). It is also unclear if this abnormality contributes to 
      impaired behavioral performance and real-world functioning. Functional imaging 
      data were recorded while individuals with SCZ, bipolar disorder with psychosis 
      (BDP) and no history of psychotic disorders (CON) attended to identity of faces 
      while ignoring their emotional expressions. We examined group differences in 
      functional connectivity between amygdala, involved in emotional evaluation, and 
      sub-regions of medial prefrontal cortex (MPFC), involved in emotion regulation 
      and cognitive control. Additionally, we examined correlation of this connectivity 
      with deficit syndrome and real-world functioning. Behaviorally, SCZ showed the 
      worst accuracy when matching the identity of emotional vs neutral faces. 
      Neurally, SCZ showed lower amygdala-MPFC connectivity than BDP and CON. BPD did 
      not differ from CON, neurally or behaviorally. In patients, reduced amygdala-MPFC 
      connectivity during emotional distractors was related to worse emotional vs 
      neutral accuracy, greater deficit syndrome severity, and unemployment. Thus, 
      reduced amygdala-MPFC functional connectivity during emotional distractors 
      reflects a deficit that is specific to SCZ. This reduction in connectivity is 
      associated with worse clinical and real-world functioning. Overall, these 
      findings provide support for the specificity and clinical utility of 
      amygdala-MPFC functional connectivity as a potential neural marker of SCZ.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the Maryland 
      Psychiatric Research Center. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Mukherjee, Prerona
AU  - Mukherjee P
AD  - University of California Davis MIND Institute, UC Davis Medical Center, 
      Sacramento, CA;
FAU - Sabharwal, Amri
AU  - Sabharwal A
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY;
FAU - Kotov, Roman
AU  - Kotov R
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY;
FAU - Szekely, Akos
AU  - Szekely A
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY;
FAU - Parsey, Ramin
AU  - Parsey R
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY;
FAU - Barch, Deanna M
AU  - Barch DM
AD  - Departments of Psychology, Psychiatry, and Radiology, Washington University in 
      St. Louis, St. Louis, MO.
FAU - Mohanty, Aprajita
AU  - Mohanty A
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY; 
      Aprajita.Mohanty@stonybrook.edu.
LA  - eng
GR  - R01 MH094398/MH/NIMH NIH HHS/United States
GR  - R01 MH094398/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160223
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amygdala/*physiopathology
MH  - Attention/*physiology
MH  - Bipolar Disorder/*physiopathology
MH  - Connectome/*methods
MH  - Emotions/*physiology
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/*physiopathology
MH  - Schizophrenia/*physiopathology
MH  - Young Adult
PMC - PMC4903065
OTO - NOTNLM
OT  - attention
OT  - bipolar
OT  - connectivity
OT  - emotion
OT  - fMRI
OT  - psychosis
OT  - schizophrenia
EDAT- 2016/02/26 06:00
MHDA- 2017/07/01 06:00
PMCR- 2017/07/01
CRDT- 2016/02/25 06:00
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - sbw012 [pii]
AID - 10.1093/schbul/sbw012 [doi]
PST - ppublish
SO  - Schizophr Bull. 2016 Jul;42(4):1056-67. doi: 10.1093/schbul/sbw012. Epub 2016 Feb 
      23.