PMID- 26909541
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20170817
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 17
IP  - 8
DP  - 2016 Aug
TI  - Immunosenescence in patients with chronic systolic heart failure.
PG  - 624-30
LID - 10.2459/JCM.0000000000000372 [doi]
AB  - AIM: Chronic heart failure (CHF) is characterized by hemodynamic compromise, 
      neurohormonal and immune activation. We sought to examine the presence and 
      severity of immunosenescence and its relation with the stages of CHF. METHODS: We 
      enrolled 86 consecutive stable systolic CHF patients and examined the 
      relationship of leukocyte and lymphocyte subpopulation counts by flow cytometry 
      with their functional status according to New York Heart Association (NYHA) 
      class. RESULTS: Patients with advanced heart failure were characterized by 
      significantly increased neutrophil and reduced lymphocyte counts. T-helper cells 
      were increased, whereas B-cells and T cytotoxic cells were decreased. T-helper 
      cells exhibited significant differentiation and aging across the NYHA classes; 
      naive T-cells, CD4 + CD45RA +, were significantly reduced in NYHA Class IV and 
      memory T-cells, CD4 + CD45RO +, were significantly increased. CONCLUSION: 
      Patients with CHF develop intense T-cell differentiation and aging. The presence 
      of significant immunosenescence in advanced CHF may indicate a population at 
      increased risk for adverse events.
FAU - Xydonas, Sotirios
AU  - Xydonas S
AD  - aSecond Department of Cardiology bDepartment of Immunology-Histocompatibility, 
      Evaggelismos General Hospital cHeart Failure Unit, Department of Cardiology, 
      National and Kapodistrian University of Athens, Attikon General Hospital, Athens 
      University dMicrobiology Department, Athens Medical School, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Parissis, John
AU  - Parissis J
FAU - Lioni, Louiza
AU  - Lioni L
FAU - Kapsimali, Violetta
AU  - Kapsimali V
FAU - Psarra, Ekaterini
AU  - Psarra E
FAU - Farmakis, Dimitrios
AU  - Farmakis D
FAU - Kremastinos, Dimitrios
AU  - Kremastinos D
FAU - Lekakis, John
AU  - Lekakis J
FAU - Sideris, Antonios
AU  - Sideris A
FAU - Tsirogianni, Alexandra
AU  - Tsirogianni A
FAU - Filippatos, Gerasimos
AU  - Filippatos G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Female
MH  - Flow Cytometry
MH  - Heart Failure, Systolic/*immunology/*physiopathology
MH  - *Hemodynamics
MH  - Humans
MH  - *Immunosenescence
MH  - Lymphocyte Subsets/*immunology
MH  - Male
MH  - Middle Aged
MH  - Ventricular Function, Left
EDAT- 2016/02/26 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/02/25 06:00
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
AID - 10.2459/JCM.0000000000000372 [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2016 Aug;17(8):624-30. doi: 
      10.2459/JCM.0000000000000372.