PMID- 26909913
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 15
IP  - 1
DP  - 2016 Jan 22
TI  - Association of IL-18 polymorphisms with rheumatoid arthritis: a meta-analysis.
LID - 10.4238/gmr.15017389 [doi]
AB  - Interleukin-18 (IL-18), an important proinflammatory cytokine, has been reported 
      to play a potential pathological role in rheumatoid arthritis (RA). Results from 
      previous studies on the association between IL-18 polymorphisms and RA are 
      conflicting. To clarify this, an updated meta-analysis of all available studies 
      on IL-18 polymorphisms and RA was conducted. Eligible articles were identified by 
      searching databases, including PubMed, Ovid, Cochrane Library, EMBASE, and China 
      Knowledge Resource Integrated Database, for the period up to May 1, 2015. The 
      pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were used to 
      assess the strength of association in the homozygote, heterozygote, dominant, 
      recessive, and additive models. The software STATA (Version 13.0) was used for 
      statistical analysis. Finally, 14 articles were included in the present 
      meta-analysis. The IL-18 -607C/A polymorphism showed pooled ORs and 95%CIs for 
      the homozygote model (AA vs CC: OR = 0.598; 95%CI = 0.395-0.907), and the 
      association between the IL-18 -137G/C polymorphism and RA showed pooled ORs and 
      95%CIs for the homozygote (CC vs GG: OR = 0.699; 95%CI = 0.364-1.342) and 
      heterozygote (CG vs GG: OR = 0.924; 95%CI = 0.803-1.064) models. In summary, the 
      current meta-analysis, which was based on the most current studies, showed that 
      the -607A/C, -920C/T, and -105A/C polymorphisms in IL-18 were significantly 
      associated with increased RA risk. However, the -137C/G polymorphism was not 
      associated with RA risk under any genetic model. More evidence is needed to 
      support or deny such a conclusion.
FAU - Li, L L
AU  - Li LL
AD  - Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Deng, X F
AU  - Deng XF
AD  - Center of Organ Transplantation, Sichuan Provincial People's Hospital, Chengdu, 
      China.
FAU - Li, J P
AU  - Li JP
AD  - Department of Nursing, West China Hospital, Sichuan University, Chengdu, China.
FAU - Ning, N
AU  - Ning N
AD  - Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Hou, X L
AU  - Hou XL
AD  - Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Chen, J L
AU  - Chen JL
AD  - Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160122
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - Asian People/genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - White People/genetics
EDAT- 2016/02/26 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/25 06:00
PHST- 2016/02/25 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - gmr7389 [pii]
AID - 10.4238/gmr.15017389 [doi]
PST - epublish
SO  - Genet Mol Res. 2016 Jan 22;15(1). doi: 10.4238/gmr.15017389.