PMID- 26911723
OWN - NLM
STAT- MEDLINE
DCOM- 20170825
LR  - 20170825
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 116
IP  - 1
DP  - 2017 Jan
TI  - Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma 
      patients.
PG  - 49-56
LID - S0929-6646(16)00048-6 [pii]
LID - 10.1016/j.jfma.2016.01.007 [doi]
AB  - BACKGROUND/PURPOSE: Decoy receptor 3 (DcR3), a soluble receptor of the tumor 
      necrosis factor receptor superfamily, is a pleiotropic immunomodulator. The aim 
      of this study was to investigate serum DcR3 levels in atopic and nonatopic asthma 
      patients. METHODS: The serum DcR3 levels of 70 adults with asthma and 20 healthy 
      controls were determined by enzyme-linked immunosorbent assay (ELISA). The asthma 
      patients were divided into atopic and nonatopic subgroups, based on the presence 
      or absence of immunoglobulin E (IgE) specific to allergen. Correlations between 
      serum DcR3 levels and blood total-eosinophil counts, forced expiratory volume in 
      1 second (FEV1), FEV1/forced vital capacity (FVC), and Asthma Control Test (ACT) 
      scores were analyzed. RESULTS: The mean serum DcR3 level was significantly higher 
      in asthma patients than in healthy controls (266.1 +/- 60.6 pg/mL vs. 
      63.7 +/- 21.9 pg/mL, p = 0.003), but there was no significant difference between 
      the mean serum DcR3 level of asthma patients with atopy (37 patients) and 
      patients without atopy (33 patients; 298.7 +/- 111.2 pg/mL vs. 230.6 +/- 38.5 pg/mL, 
      p = 0.064). However, the serum DcR3 level was positively correlated with the 
      total eosinophil count (r = 0.448, p = 0.012) and inversely correlated with the 
      percentages of predicted FEV1, FEV1/FVC, and ACT score (r = 0.409, p = 0.018; 
      r = -0.399, p = 0.021; and r = -0.505, p = 0.003, respectively) in nonatopic 
      asthma patients, but not in atopic patients. CONCLUSION: High serum DcR3 levels 
      are associated with disease severity in nonatopic asthma patients, which suggests 
      that DcR3 is a potential biomarker that can be used to predict the severity of 
      nonatopic asthma.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Chen, Ming-Han
AU  - Chen MH
AD  - Department of Medicine, National Yang-Ming University, Taipei, Taiwan; Division 
      of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans 
      General Hospital, Taipei, Taiwan.
FAU - Kan, Hung-Tsai
AU  - Kan HT
AD  - Genomics Research Center, Academia Sinica, Taipei, Taiwan.
FAU - Liu, Chun-Yu
AU  - Liu CY
AD  - Department of Medicine, National Yang-Ming University, Taipei, Taiwan.
FAU - Yu, Wen-Kuang
AU  - Yu WK
AD  - Department of Medicine, National Yang-Ming University, Taipei, Taiwan; Department 
      of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Lee, Shinn-Shing
AU  - Lee SS
AD  - Section of Allergy, Immunology, and Rheumatology, Department of Medicine, Cheng 
      Hsin Rehabilitation Medical Center, Taipei, Taiwan.
FAU - Wang, Jia-Horng
AU  - Wang JH
AD  - Critical Care, Far Eastern Memorial Hospital, Taipei, Taiwan.
FAU - Hsieh, Shie-Liang
AU  - Hsieh SL
AD  - Genomics Research Center, Academia Sinica, Taipei, Taiwan; Institute of Clinical 
      Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical 
      Research, Taipei Veterans General Hospital, Taipei, Taiwan; Institute for Cancer 
      Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan. Electronic 
      address: slhsieh@gate.sinica.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20160222
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Tumor Necrosis Factor, Member 6b)
RN  - 0 (TNFRSF6B protein, human)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asthma/*blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Receptors, Tumor Necrosis Factor, Member 6b/*blood
MH  - Respiratory Function Tests
MH  - Severity of Illness Index
MH  - Taiwan
OTO - NOTNLM
OT  - ACT score
OT  - FEV1
OT  - asthma
OT  - decoy receptor 3
OT  - total eosinophil count
EDAT- 2016/02/26 06:00
MHDA- 2017/08/26 06:00
CRDT- 2016/02/26 06:00
PHST- 2015/05/13 00:00 [received]
PHST- 2016/01/13 00:00 [revised]
PHST- 2016/01/20 00:00 [accepted]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/08/26 06:00 [medline]
PHST- 2016/02/26 06:00 [entrez]
AID - S0929-6646(16)00048-6 [pii]
AID - 10.1016/j.jfma.2016.01.007 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2017 Jan;116(1):49-56. doi: 10.1016/j.jfma.2016.01.007. Epub 
      2016 Feb 22.