PMID- 26911934
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 425
DP  - 2016 Apr 15
TI  - Endosulfan affects uterine development and functional differentiation by 
      disrupting Wnt7a and beta-catenin expression in rats.
PG  - 37-47
LID - S0303-7207(16)30038-7 [pii]
LID - 10.1016/j.mce.2016.02.011 [doi]
AB  - Neonatal exposure to a low dose of endosulfan may disrupt the expression of Wnt7a 
      and beta-catenin during uterine development leading to the failure of uterine 
      functional differentiation during implantation. New-born female Wistar rats were 
      treated with vehicle, endosulfan (600 mug/kg/d, E600) or diethylstilbestrol (0.2 
      mug/kg/d, DES) on postnatal days (PNDs) 1, 3, 5 and 7. Subsequently, uterine 
      histomorphology and the protein expression of Wnt7a and beta-catenin were evaluated 
      on PND8, PND21 and gestational day (GD) 5 (pre-implantation period). In the E600 
      rats, Wnt7a and beta-catenin protein expression was increased in the epithelium on 
      PND8, and Wnt7a expression was decreased in the endometrial glands on PND21. On 
      GD5, the number of uterine glands was decreased in the E600-and DES-treated rats. 
      In addition, Wnt7a expression was decreased in all uterine compartments, and 
      beta-catenin expression was increased in the luminal and glandular epithelia of the 
      E600-and DES-treated rats. Disruption of Wnt7a and beta-catenin uterine expression 
      in the prepubertal and adult females altered the uterine preparation for embryo 
      implantation, which could be associated with the subfertility triggered by 
      endosulfan.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Ingaramo, Paola I
AU  - Ingaramo PI
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Milesi, Maria M
AU  - Milesi MM
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Schimpf, Marlise Guerrero
AU  - Schimpf MG
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Ramos, Jorge G
AU  - Ramos JG
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Vigezzi, Lucia
AU  - Vigezzi L
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Munoz-de-Toro, Monica
AU  - Munoz-de-Toro M
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Luque, Enrique H
AU  - Luque EH
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Varayoud, Jorgelina
AU  - Varayoud J
AD  - Instituto de Salud y Ambiente Del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional Del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina. Electronic address: 
      varayoud@fbcb.unl.edu.ar.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160218
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt7a protein, rat)
RN  - 0 (beta Catenin)
RN  - 731DCA35BT (Diethylstilbestrol)
RN  - OKA6A6ZD4K (Endosulfan)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Differentiation/drug effects
MH  - Diethylstilbestrol/toxicity
MH  - Endosulfan/administration & dosage/*adverse effects
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Uterus/*drug effects/growth & development/metabolism
MH  - Wnt Proteins/*metabolism
MH  - beta Catenin/*metabolism
OTO - NOTNLM
OT  - Endosulfan
OT  - Implantation
OT  - Uterus
OT  - Wnt7a
OT  - beta-catenin
EDAT- 2016/02/26 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/26 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2016/02/12 00:00 [revised]
PHST- 2016/02/12 00:00 [accepted]
PHST- 2016/02/26 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0303-7207(16)30038-7 [pii]
AID - 10.1016/j.mce.2016.02.011 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2016 Apr 15;425:37-47. doi: 10.1016/j.mce.2016.02.011. Epub 
      2016 Feb 18.