PMID- 26911952
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20181202
IS  - 2095-4352 (Print)
VI  - 28
IP  - 2
DP  - 2016 Feb
TI  - [The diagnostic value of high-sensitivity C-reactive protein/albumin ratio in 
      evaluating early-onset infection in premature].
PG  - 173-7
LID - 10.3760/cma.j.issn.2095-4352.2016.02.017 [doi]
AB  - OBJECTIVE: To observe the diagnostic value of high-sensitivity C-reactive 
      protein/albumin ratio (hs-CRP/ALB) in early-onset infection in premature and its 
      clinical significance. METHODS: Clinical data of premature patients with high 
      risk factors of intrauterine infection admitted to neonatal intensive care unit 
      (NICU) of Liaocheng People's Hospital in Shandong Province from July 2013 to July 
      2015 were analyzed retrospectively. They were divided into infection and 
      non-infection groups, as well as survival and death groups according to the 
      outcome of the premature babies. The pre-albumin (PA), ALB, white blood cell 
      count (WBC), platelet count (PLT), and hs-CRP at the moment of NICU admission (0 
      hour) and 24, 48 and 72 hours after NICU admission were compared. The receiver 
      operating characteristic (ROC) curve was plotted for evaluation of the predictive 
      value of serum hs-CRP/ALB ratio for the babies during hospitalization. RESULTS: A 
      total of 214 cases of premature infants were enrolled, with 102 cases in 
      infection group, and 112 in non-infection group. In infection neonates, 97 of 
      them survived, and 5 died. (1) The level of hs-CRP after NICU admission was 
      increased in infection and non-infection groups, and it was significantly higher 
      at 48 hours in infection group than that of the non-infection group [mg/L: 22.0 
      (7.6, 40.4) vs. 18.3 (12.9, 23.4),Z = 5.257,P = 0.038]. Then hs-CRP was decreased 
      in non-infection, but it was persistently increased in infection group, and it 
      was significantly higher at 72 hours in infection group than that of the 
      non-infection group [mg/L: 25.5 (9.8, 43.5) vs. 12.2 (1.9, 22.1), Z = 5.879, P = 
      0.042]. The levels of ALB and WBC in infection group was significantly lower than 
      those of the non-infection group [ALB (g/L): 27.9+/-2.7 vs. 29.1+/-2.9, t = 5.178, P 
      = 0.026; WBC (x109/L): 13.7+/-7.1 vs. 16.1+/-7.9, t = 4.368, P = 0.037], and at 48 
      hours hs-CRP/ALB in infection group was significantly higher than that of 
      non-infection group [0.16 (0.08, 0.57) vs. 0.07 (0.00, 0.23), Z = 3.436, P = 
      0.042]. There was no significant difference in PA and PLT between infection and 
      non-infection groups. (2) In premature patients with infection, ALB in 
      non-survival group was decreased (g/L: 20.4+/-6.9 vs. 29.6+/-7.5, t = 7.859, P = 
      0.003), and 48-hour hs-CRP and hs-CRP/ALB ratio was significantly increased when 
      compared with that of survival group [hs-CRP (mg/L): 25.8 (15.6, 54.8) vs. 18.2 
      (12.9, 36.2), Z = 4.067, P = 0.043; hs-CRP/ALB: 0.31 (0.28, 0.76) vs. 0.06 (0.00, 
      0.21), Z = 6.102, P = 0.011].(3) It was shown by ROC curve analysis that the area 
      under ROC curve (AUC) of 48-hour hs-CRP/ALB ratio for evaluating infection was 
      0.765, when the cut-off of 48-hour hs-CRP/ALB ratio was 0.08, the sensitivity was 
      84.2%, and the specificity was 76.3%. CONCLUSIONS: The values of hs-CRP and ALB 
      can be used as effective indexes in early diagnosis of intrauterine bacterial 
      infection, and increase in 48-hour hs-CRP/ALB can improve the sensitivity of the 
      diagnosis. Hs-CRP/ALB can be combined to guide rational use of antibiotics.
FAU - Yang, Chunyan
AU  - Yang C
AD  - Department of Pediatric Neonatal Intensive Care Unit, Liaocheng People's 
      Hospital, Liaocheng 252000, Shandong, China. Corresponding author: Xu Ping, 
      Email: 280304979@qq.com.
FAU - Yang, Yujun
AU  - Yang Y
FAU - Li, Baoyun
AU  - Li B
FAU - Xu, Ping
AU  - Xu P
FAU - Shen, Qinghua
AU  - Shen Q
FAU - Yang, Qiaozhi
AU  - Yang Q
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhonghua wei zhong bing ji jiu yi xue
JID - 101604552
RN  - 0 (Serum Albumin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Bacterial Infections/blood/*diagnosis
MH  - C-Reactive Protein/*analysis
MH  - Early Diagnosis
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/*blood
MH  - Intensive Care Units, Neonatal
MH  - Leukocyte Count
MH  - Platelet Count
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Serum Albumin/*analysis
EDAT- 2016/02/26 06:00
MHDA- 2016/10/21 06:00
CRDT- 2016/02/26 06:00
PHST- 2016/02/26 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
AID - 10.3760/cma.j.issn.2095-4352.2016.02.017 [doi]
PST - ppublish
SO  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016 Feb;28(2):173-7. doi: 
      10.3760/cma.j.issn.2095-4352.2016.02.017.