PMID- 2691207
OWN - NLM
STAT- MEDLINE
DCOM- 19900216
LR  - 20240222
IS  - 0197-2456 (Print)
IS  - 0197-2456 (Linking)
VI  - 10
IP  - 4
DP  - 1989 Dec
TI  - Measurement of health status. Ascertaining the minimal clinically important 
      difference.
PG  - 407-15
AB  - In recent years quality of life instruments have been featured as primary 
      outcomes in many randomized trials. One of the challenges facing the investigator 
      using such measures is determining the significance of any differences observed, 
      and communicating that significance to clinicians who will be applying the trial 
      results. We have developed an approach to elucidating the significance of changes 
      in score in quality of life instruments by comparing them to global ratings of 
      change. Using this approach we have established a plausible range within which 
      the minimal clinically important difference (MCID) falls. In three studies in 
      which instruments measuring dyspnea, fatigue, and emotional function in patients 
      with chronic heart and lung disease were applied the MCID was represented by mean 
      change in score of approximately 0.5 per item, when responses were presented on a 
      seven point Likert scale. Furthermore, we have established ranges for changes in 
      questionnaire scores that correspond to moderate and large changes in the domains 
      of interest. This information will be useful in interpreting questionnaire 
      scores, both in individuals and in groups of patients participating in controlled 
      trials, and in the planning of new trials.
FAU - Jaeschke, R
AU  - Jaeschke R
AD  - Department of Clinical Epidemiology and Biostatistics, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Singer, J
AU  - Singer J
FAU - Guyatt, G H
AU  - Guyatt GH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Control Clin Trials
JT  - Controlled clinical trials
JID - 8006242
SB  - IM
CIN - Acta Orthop. 2016 Jul;87 Suppl 1:3-8. PMID: 27168175
MH  - Activities of Daily Living
MH  - Affective Symptoms/diagnosis
MH  - Attitude to Health
MH  - Clinical Trials as Topic
MH  - Data Interpretation, Statistical
MH  - Dyspnea/diagnosis
MH  - Fatigue/diagnosis
MH  - *Health Status Indicators
MH  - Heart Diseases/diagnosis
MH  - Humans
MH  - Lung Diseases/diagnosis
MH  - *Quality of Life
MH  - Research Design
MH  - Surveys and Questionnaires
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
AID - 0197-2456(89)90005-6 [pii]
AID - 10.1016/0197-2456(89)90005-6 [doi]
PST - ppublish
SO  - Control Clin Trials. 1989 Dec;10(4):407-15. doi: 10.1016/0197-2456(89)90005-6.