PMID- 26913408
OWN - NLM
STAT- MEDLINE
DCOM- 20160621
LR  - 20181202
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 24
IP  - 1
DP  - 2016 Feb
TI  - [Cytogenetic Abnormalities and Outcomes of 117 Patients with Multiple Myeloma 
      Detected by FISH].
PG  - 127-30
LID - 10.7534/j.issn.1009-2137.2016.01.025 [doi]
AB  - OBJECTIVE: To analyze the cytogenetic abnormalities and prognostic outcomes of 
      patients with multiple myeloma (MM) detected by fluorescence in situ 
      hybridization (FISH). METHODS: The clinical record of 117 newly-diagnosed 
      patients with MM treated in department of hematology and geriatric hematology of 
      our hospital for 7 years were collected, and their molecular cytogenetic 
      abnormalities detected by FISH and the clinical outcome were analyzed 
      retrospectively. RESULTS: The detected rate of cytogenetic abnormality was 
      76.9%(90/117), the most common abnormality deteted by FISH was 1q21+ (71.1%), 
      followed by 13q- (56.6%). The cross comparison method showed that 13q- and 
      17p13-, t(11;14) and t(4;14) were related respectively. All the patients with 
      cytogenetic abnormalities showed no significant difference in the overall 
      survival from cytogenetic normal patients. CONCLUSION: The positive rate of 
      molecular cytogenetic abnormalities detected by FISH in MM patients is high, but 
      data from larger and longer studies are needed to evaluate the prognostic 
      outcomes.
FAU - Zhai, Bing
AU  - Zhai B
AD  - Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Zou, Dan-Dan
AU  - Zou DD
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Yan, Jian-Jun
AU  - Yan JJ
AD  - Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China.
FAU - Wang, Nan
AU  - Wang N
AD  - Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Wang, Li-Li
AU  - Wang LL
AD  - Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Zhu, Hong-Li
AU  - Zhu HL
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Huang, Wen-Rong
AU  - Huang WR
AD  - Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Yu, Li
AU  - Yu L
AD  - Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China. 
      E-mail: liyu301@vip.163.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Cytogenetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Multiple Myeloma/diagnosis/*genetics
MH  - Prognosis
MH  - Retrospective Studies
MH  - Translocation, Genetic
EDAT- 2016/02/26 06:00
MHDA- 2016/06/22 06:00
CRDT- 2016/02/26 06:00
PHST- 2016/02/26 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2016/06/22 06:00 [medline]
AID - 1009-2137(2016)01-0127-04 [pii]
AID - 10.7534/j.issn.1009-2137.2016.01.025 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Feb;24(1):127-30. doi: 
      10.7534/j.issn.1009-2137.2016.01.025.