PMID- 26913549
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1532-2378 (Electronic)
IS  - 1049-5398 (Linking)
VI  - 27
IP  - 2
DP  - 2016
TI  - Protective Effect of Adansonia digitata against Isoproterenol-Induced Myocardial 
      Injury in Rats.
PG  - 84-95
LID - 10.1080/10495398.2015.1102147 [doi]
AB  - The baobab fruit (Adansonia digitata) was analyzed for proximate composition, 
      amino acids, and minerals. The fruit pulp was found to be a good source of 
      carbohydrates, proteins, phenols, and substantial quantities of K, Ca, and Mg. 
      Amino acid analyses revealed high glutamic and aspartic acid, but the sulfur 
      amino acids were the most limited. The present study was designed to investigate 
      the role of Adansonia digitata (Baobab fruit pulp) against isoproterenol induced 
      myocardial oxidative stress in experimental rats by demonstrating the changes in 
      tissue cardiac markers, some antioxidant enzymes, interleukin-1 beta (IL-1 beta), 
      monocyte chemoattractant protein-1(MCP-1), myeloperoxidase (MPO), Collagen-1, 
      galectin-3, and serum corticosterone. The activities of enzymatic antioxidant 
      glutathione peroxidase (GPX) and non-enzymatic antioxidant reduced glutathione 
      (GSH) in the heart tissue; additionally, histopathological examination of the 
      heart was estimated. Male albino rats were randomly divided into four groups of 
      ten animals each. Group I served as normal control animal. Group II animals 
      received isoproterenol (ISP) (85 mg/kg body weight intraperitonealy (i.p.) to 
      develop myocardial injury. Group III were myocardial oxidative animals treated 
      with Baobab fruit pulp (200 microg/rats/day) for 4 weeks. Group IV received Baobab 
      fruit pulp only. The data suggested an isoproterenol increase in levels of 
      cardiac marker enzymes [creatine kinase MB (CK- MB), lactate dehydrogenase (LDH), 
      and aspartate aminotransferase (AST)], IL-1ss, MCP-1, MPO, Collagen, and 
      galectin-3, with concomitant decrease in the activities GPX and GSH in heart 
      tissue as well as corticosterone in serum. Baobab fruit pulp brings all the 
      parameters to near normal level in ISP-induced myocardial infarction in rats. 
      Histopathological examination of heart tissue of ISP-administered model rat 
      showed infiltration of inflammatory cells and congestion in the blood vessels. 
      However, treatment with Baobab fruit pulp (200 microg/rats/day) showed predominantly 
      normal myocardial structure and no inflammatory cell infiltration. It has been 
      concluded that Baobab fruit pulp has cardio protective effect against ISP-induced 
      oxidative stress in rats.
FAU - Ghoneim, Mona A M
AU  - Ghoneim MA
AD  - a Department of Radioisotopes, Nuclear Research Centre , Atomic Energy Authority 
      , Giza , Egypt.
FAU - Hassan, Amal I
AU  - Hassan AI
AD  - a Department of Radioisotopes, Nuclear Research Centre , Atomic Energy Authority 
      , Giza , Egypt.
FAU - Mahmoud, Manal G
AU  - Mahmoud MG
AD  - b Microbial Biotechnology Department , National Research Centre , Dokki , Cairo , 
      Egypt.
FAU - Asker, Mohsen S
AU  - Asker MS
AD  - b Microbial Biotechnology Department , National Research Centre , Dokki , Cairo , 
      Egypt.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Anim Biotechnol
JT  - Animal biotechnology
JID - 9011409
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Adansonia/*chemistry
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Female
MH  - Fruit/chemistry
MH  - Heart/*drug effects
MH  - Isoproterenol/adverse effects
MH  - Myocardial Infarction/*chemically induced/metabolism
MH  - Myocardium/chemistry/metabolism
MH  - Oxidative Stress/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats
OTO - NOTNLM
OT  - Baobab fruit pulp
OT  - chemical composition
OT  - isoproterenol
OT  - oxidative stress
EDAT- 2016/02/26 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/26 06:00
PHST- 2016/02/26 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1080/10495398.2015.1102147 [doi]
PST - ppublish
SO  - Anim Biotechnol. 2016;27(2):84-95. doi: 10.1080/10495398.2015.1102147.