PMID- 26914392
OWN - NLM
STAT- MEDLINE
DCOM- 20171201
LR  - 20181202
IS  - 1541-2563 (Electronic)
IS  - 1541-2563 (Linking)
VI  - 13
IP  - 3
DP  - 2016 Jun
TI  - The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A 
      Systematic Review.
PG  - 399-406
LID - 10.3109/15412555.2016.1140732 [doi]
AB  - Type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases (CVD) are common in 
      patients with chronic obstructive pulmonary disease (COPD). Prevention of these 
      co-morbidities in COPD requires knowledge on their risk factors. Metabolic 
      syndrome (MetS) predisposes to the development of T2DM and CVD but its prevalence 
      in COPD remains unclear. The aim of this review was to assess the prevalence of 
      MetS and its components in COPD patients compared to controls and to investigate 
      the contribution of clinical characteristics to MetS prevalence. We 
      systematically searched PubMed and EMBASE for original studies in COPD that have 
      investigated the prevalence of MetS and its components. In total, 19 studies 
      involving 4208 COPD patients were included. The pooled MetS prevalence was 34%. 
      Compared to controls, the prevalence was higher in COPD (10 studies, 32% and 30%, 
      p = 0.001). The three most prevalent components in both COPD and controls were 
      arterial hypertension (56% and 51%), abdominal obesity (39% and 38%) and 
      hyperglycemia (44% and 47%). Compared to COPD patients without MetS, those with 
      MetS had higher body mass index (BMI) (29.9 and 24.6 kg/m(2), p < 0.001), higher 
      forced expiratory volume in 1 second (FEV1) % predicted (54 and 51, p < 0.001) 
      and were more frequently female (31% and 25%, p = 0.011). In conclusion, the 
      prevalence of MetS in COPD patients is high and hypertension, abdominal obesity 
      and hyperglycemia are the most prevalent components. Further studies are needed 
      to evaluate the impact of lifestyle factors and medications on MetS in COPD.
FAU - Cebron Lipovec, Nanca
AU  - Cebron Lipovec N
AD  - a Department of Respiratory Medicine , NUTRIM School of Nutrition and 
      Translational Research in Metabolism, Maastricht University Medical Centre , 
      Maastricht , The Netherlands.
AD  - b University Clinic of Pulmonary and Allergic Diseases Golnik , Slovenia.
FAU - Beijers, Rosanne J H C G
AU  - Beijers RJ
AD  - a Department of Respiratory Medicine , NUTRIM School of Nutrition and 
      Translational Research in Metabolism, Maastricht University Medical Centre , 
      Maastricht , The Netherlands.
FAU - van den Borst, Bram
AU  - van den Borst B
AD  - a Department of Respiratory Medicine , NUTRIM School of Nutrition and 
      Translational Research in Metabolism, Maastricht University Medical Centre , 
      Maastricht , The Netherlands.
FAU - Doehner, Wolfram
AU  - Doehner W
AD  - c Center for Stroke Research Berlin, Charite Medical School , Berlin , Germany.
FAU - Lainscak, Mitja
AU  - Lainscak M
AD  - d Department of Cardiology , General Hospital Celje , Celje , Slovenia.
AD  - e Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia.
FAU - Schols, Annemie M W J
AU  - Schols AM
AD  - a Department of Respiratory Medicine , NUTRIM School of Nutrition and 
      Translational Research in Metabolism, Maastricht University Medical Centre , 
      Maastricht , The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20160225
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Arterial Pressure
MH  - Body Mass Index
MH  - Comorbidity
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Hyperglycemia/*epidemiology
MH  - Hypertension/*epidemiology
MH  - Metabolic Syndrome/*epidemiology
MH  - Obesity, Abdominal/*epidemiology
MH  - Prevalence
MH  - Pulmonary Disease, Chronic Obstructive/*epidemiology/physiopathology
MH  - Sex Factors
OTO - NOTNLM
OT  - Co-morbidities
OT  - components
OT  - lifestyle
OT  - prevalence
EDAT- 2016/02/26 06:00
MHDA- 2017/12/02 06:00
CRDT- 2016/02/26 06:00
PHST- 2016/02/26 06:00 [entrez]
PHST- 2016/02/26 06:00 [pubmed]
PHST- 2017/12/02 06:00 [medline]
AID - 10.3109/15412555.2016.1140732 [doi]
PST - ppublish
SO  - COPD. 2016 Jun;13(3):399-406. doi: 10.3109/15412555.2016.1140732. Epub 2016 Feb 
      25.