PMID- 26915743
OWN - NLM
STAT- MEDLINE
DCOM- 20170201
LR  - 20181113
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 30
IP  - 5
DP  - 2016 May
TI  - Stellate nonhereditary idiopathic foveomacular retinoschisis concomitant to 
      exudative maculopathies.
PG  - 754-7
LID - 10.1038/eye.2016.17 [doi]
AB  - PurposeTo report the clinical course of patients presenting with stellate 
      nonhereditary idiopathic foveomacular retinoschisis (SNIFR) concomitant with 
      exudative maculopathies.MethodsRetrospective case series. Multimodal imaging 
      findings, including spectral-domain optical coherence tomography (SD-OCT) were 
      reviewed. Genetic testing for the RS1 gene was performed in one patient.ResultsWe 
      identified two female patients who fit the definition of SNIFR and presented with 
      concomitant neovascular age-related macular degeneration (n-AMD). In both the 
      patients, SD-OCT showed exudative macular features and splitting (bilateral in 
      patient 1, unilateral in patient 2) of the outer plexiform layer (OPL) in the 
      macula with no other evidence of hereditary or an acquired predisposing 
      condition. Genetic testing excluded mutation of RS1 gene in patient 1. The fundi 
      of both the patients showed characteristic signs of active choroidal 
      neovascularization (CNV) and following anti-VEGF treatment, visual acuity 
      improved and CNV-related exudative changes resolved. However, the split along the 
      OPL remained unaltered.ConclusionsSNIFR may be associated with n-AMD. It is 
      important to recognise the presence of retinoschisis when there is other 
      exudative pathology as the former may be misinterpreted as intraretinal fluid, 
      prompting unnecessary treatment.
FAU - Casalino, G
AU  - Casalino G
AD  - Belfast Health and Social Care Trust and Centre for Experimental Medicine, 
      Queen's University Belfast, Belfast, UK.
AD  - Scientific Institute San Raffaele, Vita-Salute University, Milan, Italy.
FAU - Upendran, M
AU  - Upendran M
AD  - Belfast Health and Social Care Trust and Centre for Experimental Medicine, 
      Queen's University Belfast, Belfast, UK.
FAU - Bandello, F
AU  - Bandello F
AD  - Scientific Institute San Raffaele, Vita-Salute University, Milan, Italy.
FAU - Chakravarthy, U
AU  - Chakravarthy U
AD  - Belfast Health and Social Care Trust and Centre for Experimental Medicine, 
      Queen's University Belfast, Belfast, UK.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160226
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Coloring Agents)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Aged, 80 and over
MH  - Angiogenesis Inhibitors/therapeutic use
MH  - Coloring Agents/administration & dosage
MH  - Exudates and Transudates
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green/administration & dosage
MH  - Multimodal Imaging
MH  - Retinoschisis/*complications/diagnostic imaging
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/antagonists & inhibitors
MH  - Visual Acuity/physiology
MH  - Wet Macular Degeneration/*complications/diagnostic imaging/drug therapy
PMC - PMC4869130
EDAT- 2016/02/27 06:00
MHDA- 2017/02/02 06:00
PMCR- 2017/05/01
CRDT- 2016/02/27 06:00
PHST- 2015/10/29 00:00 [received]
PHST- 2016/01/04 00:00 [accepted]
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2017/02/02 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - eye201617 [pii]
AID - 10.1038/eye.2016.17 [doi]
PST - ppublish
SO  - Eye (Lond). 2016 May;30(5):754-7. doi: 10.1038/eye.2016.17. Epub 2016 Feb 26.