PMID- 26916633
OWN - NLM
STAT- MEDLINE
DCOM- 20170322
LR  - 20170817
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 88
IP  - 1
DP  - 2016 Jul
TI  - Very late stent thrombosis with second generation drug eluting stents compared to 
      bare metal stents: Network meta-analysis of randomized primary percutaneous 
      coronary intervention trials.
PG  - 38-48
LID - 10.1002/ccd.26458 [doi]
AB  - BACKGROUND: The relative safety of drug-eluting stents (DES) and bare-metal 
      stents (BMS) in primary percutaneous coronary intervention (PPCI) in ST elevation 
      myocardial infarction (STEMI) continues to be debated. The long-term clinical 
      outcomes between second generation DES and BMS for primary percutaneous coronary 
      intervention (PCI) using network meta-analysis were compared. METHODS: Randomized 
      controlled trials comparing stent types (first generation DES, second generation 
      DES, or BMS) were considered for inclusion. A search strategy used Medline, 
      Embase, Cochrane databases, and proceedings of international meetings. 
      Information about study design, inclusion criteria, and sample characteristics 
      were extracted. Network meta-analysis was used to pool direct (comparison of 
      second generation DES to BMS) and indirect evidence (first generation DES with 
      BMS and second generation DES) from the randomized trials. RESULTS: Twelve trials 
      comparing all stents types including 9,673 patients randomly assigned to 
      treatment groups were analyzed. Second generation DES was associated with 
      significantly lower incidence of definite or probable ST (OR 0.59, 95% CI 
      0.39-0.89), MI (OR 0.59, 95% CI 0.39-0.89), and TVR at 3 years (OR 0.50: 95% CI 
      0.31-0.81) compared with BMS. In addition, there was a significantly lower 
      incidence of MACE with second generation DES versus BMS (OR 0.54, 95% CI 
      0.34-0.74) at 3 years. These were driven by a higher rate of TVR, MI and stent 
      thrombosis in the BMS group at 3 years. There was a non-significant reduction in 
      the overall and cardiac mortality [OR 0.83, 95% CI (0.60-1.14), OR 0.88, 95% CI 
      (0.6-1.28)] with the use of second generation DES versus BMS at 3 years. 
      CONCLUSIONS: Network meta-analysis of randomized trials of primary PCI 
      demonstrated lower incidence of MACE, MI, TVR, and stent thrombosis with second 
      generation DES compared with BMS. (c) 2016 Wiley Periodicals, Inc.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Philip, Femi
AU  - Philip F
AD  - Department of Internal Medicine and Biostatistics, University of California, 
      Davis, California.
FAU - Stewart, Susan
AU  - Stewart S
AD  - Department of Internal Medicine and Biostatistics, University of California, 
      Davis, California.
FAU - Southard, Jeffrey A
AU  - Southard JA
AD  - Department of Internal Medicine and Biostatistics, University of California, 
      Davis, California.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20160224
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
RN  - 0 (Metals)
SB  - IM
CIN - Catheter Cardiovasc Interv. 2016 Jul;88(1):49-50. PMID: 27400635
MH  - Coronary Thrombosis/diagnosis/*etiology/mortality/therapy
MH  - Drug-Eluting Stents
MH  - Humans
MH  - *Metals
MH  - Network Meta-Analysis
MH  - Odds Ratio
MH  - Percutaneous Coronary Intervention/adverse effects/*instrumentation/mortality
MH  - Prosthesis Design
MH  - Randomized Controlled Trials as Topic
MH  - Recurrence
MH  - Retreatment
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/diagnosis/mortality/*therapy
MH  - *Stents
MH  - Stroke/etiology
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - acute myocardial infarction
OT  - drug-eluting stent
OT  - percutaneous coronary intervention
EDAT- 2016/02/27 06:00
MHDA- 2017/03/23 06:00
CRDT- 2016/02/27 06:00
PHST- 2015/08/19 00:00 [received]
PHST- 2015/11/05 00:00 [revised]
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
AID - 10.1002/ccd.26458 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2016 Jul;88(1):38-48. doi: 10.1002/ccd.26458. Epub 
      2016 Feb 24.