PMID- 26917204
OWN - NLM
STAT- MEDLINE
DCOM- 20170420
LR  - 20220331
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 74
IP  - 7
DP  - 2016 Jul
TI  - Lip Cancer: A Clinicopathological Study and Treatment Outcomes in a 25-Year 
      Experience.
PG  - 1360-7
LID - S0278-2391(16)00133-6 [pii]
LID - 10.1016/j.joms.2016.01.041 [doi]
AB  - PURPOSE: There are few clinical studies focusing on treatment outcomes of lip 
      cancer. This study investigated the clinicopathologic variables of a large sample 
      of patients with lip squamous cell carcinoma (LSCC) treated in a reference head 
      and neck cancer center for the past 25 years and analyzed the influence of these 
      variables on treatment outcomes. MATERIALS AND METHODS: This retrospective cohort 
      study reviewed the clinical records of patients with LSCC. Epidemiologic data 
      were age, gender, ethnicity, type of occupation, tobacco smoking, alcohol 
      consumption, comorbid conditions, and family cancer history. Clinicopathologic 
      features included the lip location of the tumor, TNM classification, clinical 
      staging, histopathologic grade, surgical margin analysis, and treatment modality. 
      Local recurrence, second primary tumor, and survival were the outcome variables. 
      Statistical analysis was performed by chi(2) test, Fisher exact test, and binary 
      logistic regression analysis. Survival analysis was assessed through the 
      Kaplan-Meier curve. Level of statistical significance was set at a P value less 
      than .05 for all tests. RESULTS: In total, 144 patients with LSCC were studied. 
      There were 117 men (81.25%) and 27 women (18.75%) with a mean age of 60.21 years. 
      One hundred thirty-four patients (93.05%) were considered of white ethnicity, and 
      in 57 cases (39.58%), the patients reported an occupation that was related to 
      long-term solar exposure. Most cancers had initial clinical staging of 1 or 2 
      (84.02%). Microscopically, lesions were predominantly well (43.05%) and 
      moderately (40.96%) differentiated tumors. Clinical staging was related to a 
      specific higher survival rate (P = .0049). One hundred twelve cases (77.78%) 
      underwent surgical treatment and only 6 patients (4.80%) had local recurrence, 
      which was directly associated with compromised surgical margins (P = .0320). 
      CONCLUSION: A high success rate in LSCC treatment was observed in this study. 
      Compromised surgical margin was associated with tumor recurrence and is a 
      critical event in lip cancer treatment.
CI  - Copyright (c) 2016 American Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Inc. All rights reserved.
FAU - Biasoli, Eder Ricardo
AU  - Biasoli ER
AD  - Adjunct Professor, Oral Oncology Center, Aracatuba Dental School, Univ Estadual 
      Paulista (UNESP), Aracatuba, SP, Brazil.
FAU - Valente, Vitor Bonetti
AU  - Valente VB
AD  - MS Student in Stomatology, Oral Oncology Center, Aracatuba Dental School, Univ 
      Estadual Paulista (UNESP), Aracatuba, SP, Brazil.
FAU - Mantovan, Bruna
AU  - Mantovan B
AD  - Dental Surgeon, Oral Oncology Center, Aracatuba Dental School, Univ Estadual 
      Paulista (UNESP), Aracatuba, SP, Brazil.
FAU - Collado, Francisco Urbano
AU  - Collado FU
AD  - Oncologist, Oral Oncology Center, Aracatuba Dental School, Univ Estadual Paulista 
      (UNESP), Aracatuba, SP, Brazil.
FAU - Neto, Sebastiao Conrado
AU  - Neto SC
AD  - Head and Neck Surgeon, Oral Oncology Center, Aracatuba Dental School, Univ 
      Estadual Paulista (UNESP), Aracatuba, SP, Brazil.
FAU - Sundefeld, Maria Lucia Marcal Mazza
AU  - Sundefeld ML
AD  - Adjunct Professor, Oral Oncology Center, Aracatuba Dental School, Univ Estadual 
      Paulista (UNESP), Aracatuba, SP, Brazil.
FAU - Miyahara, Glauco Issamu
AU  - Miyahara GI
AD  - Adjunct Professor, Oral Oncology Center, Aracatuba Dental School, Univ Estadual 
      Paulista (UNESP), Aracatuba, SP, Brazil.
FAU - Bernabe, Daniel Galera
AU  - Bernabe DG
AD  - Assistant Professor, Oral Oncology Center, Aracatuba Dental School, Univ Estadual 
      Paulista (UNESP), Aracatuba, SP, Brazil. Electronic address: 
      danielbernabe@foa.unesp.br.
LA  - eng
PT  - Journal Article
DEP - 20160130
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American 
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
MH  - Carcinoma, Squamous Cell/epidemiology/*pathology/*surgery
MH  - Female
MH  - Humans
MH  - Lip Neoplasms/epidemiology/*pathology/*surgery
MH  - Male
MH  - Margins of Excision
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2016/02/27 06:00
MHDA- 2017/04/21 06:00
CRDT- 2016/02/27 06:00
PHST- 2015/10/22 00:00 [received]
PHST- 2016/01/21 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2017/04/21 06:00 [medline]
AID - S0278-2391(16)00133-6 [pii]
AID - 10.1016/j.joms.2016.01.041 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2016 Jul;74(7):1360-7. doi: 10.1016/j.joms.2016.01.041. 
      Epub 2016 Jan 30.