PMID- 26917333
OWN - NLM
STAT- MEDLINE
DCOM- 20170505
LR  - 20220318
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 115
IP  - 8
DP  - 2016 Apr
TI  - Dietary supplementation with beta-hydroxy-beta-methylbutyrate calcium during the early 
      postnatal period accelerates skeletal muscle fibre growth and maturity in 
      intra-uterine growth-retarded and normal-birth-weight piglets.
PG  - 1360-9
LID - 10.1017/S0007114516000465 [doi]
AB  - Intra-uterine growth restriction (IUGR) impairs postnatal growth and skeletal 
      muscle development in neonatal infants. This study evaluated whether dietary 
      beta-hydroxy-beta-methylbutyrate Ca (HMB-Ca) supplementation during the early postnatal 
      period could improve muscle growth in IUGR neonates using piglets as a model. A 
      total of twelve pairs of IUGR and normal-birth-weight (NBW) male piglets with 
      average initial weights (1.85 (sem 0.36) and 2.51 (sem 0.39) kg, respectively) 
      were randomly allotted to groups that received milk-based diets (CON) or 
      milk-based diets supplemented with 800 mg/kg HMB-Ca (HMB) during days 7-28 after 
      birth. Blood and longissimus dorsi (LD) samples were collected and analysed for 
      plasma amino acid content, fibre morphology and the expression of genes related 
      to muscle development. The results indicate that, regardless of diet, IUGR 
      piglets had a significantly decreased average daily weight gain (ADG) compared 
      with that of NBW piglets (P<0.05). However, IUGR piglets fed HMB-Ca had a net 
      weight and ADG similar to that of NBW piglets fed the CON diet. Irrespective of 
      body weight (BW), HMB-Ca supplementation markedly increased the type II fibre 
      cross-sectional area and the mRNA expression of mammalian target of rapamycin 
      (mTOR), insulin-like growth factor-1 and myosin heavy-chain isoform IIb in the LD 
      of piglets (P<0.05). Moreover, there was a significant interaction between the 
      effects of BW and HMB on mTOR expression in the LD (P<0.05). In conclusion, 
      HMB-Ca supplementation during the early postnatal period could improve skeletal 
      muscle growth and maturity by accelerating fast-twitch glycolytic fibre 
      development in piglets.
FAU - Wan, Haifeng
AU  - Wan H
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Zhu, Jiatao
AU  - Zhu J
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Su, Guoqi
AU  - Su G
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Hua, Lun
AU  - Hua L
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Hu, Liang
AU  - Hu L
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Wu, Caimei
AU  - Wu C
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Zhang, Ruinan
AU  - Zhang R
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Zhou, Pan
AU  - Zhou P
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Shen, Yong
AU  - Shen Y
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Lin, Yan
AU  - Lin Y
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Xu, Shengyu
AU  - Xu S
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Fang, Zhengfeng
AU  - Fang Z
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Che, Lianqiang
AU  - Che L
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Feng, Bin
AU  - Feng B
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
FAU - Wu, De
AU  - Wu D
AD  - Institute of Animal Nutrition,Sichuan Agricultural University,No. 211,Huimin 
      Road,Wenjiang District,Chengdu,Sichuan 611130,People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20160226
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Calcium, Dietary)
RN  - 0 (RNA, Messenger)
RN  - 0 (Valerates)
RN  - 3F752311CD (beta-hydroxyisovaleric acid)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animal Feed
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Animals, Newborn/*growth & development
MH  - Birth Weight
MH  - Calcium, Dietary/*administration & dosage
MH  - Dietary Supplements
MH  - Fetal Growth Retardation/physiopathology/*veterinary
MH  - Gene Expression
MH  - Glycolysis
MH  - Male
MH  - Muscle Fibers, Fast-Twitch/metabolism/physiology
MH  - Muscle Fibers, Skeletal/physiology
MH  - Muscle, Skeletal/chemistry/*growth & development
MH  - RNA, Messenger
MH  - Sus scrofa
MH  - Swine
MH  - Swine Diseases/*physiopathology
MH  - TOR Serine-Threonine Kinases/genetics
MH  - Valerates/*administration & dosage
MH  - Weight Gain
OTO - NOTNLM
OT  - BW body weight
OT  - CK creatine kinase
OT  - CON control
OT  - CSA cross-sectional area
OT  - Growth and development
OT  - HMB beta-hydroxy-beta-methylbutyrate
OT  - HMB-Ca beta-hydroxy-beta-methylbutyrate calcium
OT  - IGF-1 insulin-like growth factor-1
OT  - IUGR intra-uterine growth restriction
OT  - LD longissimus dorsi
OT  - LDH lactate dehydrogenase
OT  - MRF-4 muscle regulatory factor 4
OT  - MyHC myosin heavy-chain
OT  - NBW normal birth weight
OT  - Piglets
OT  - Skeletal muscle fibre
OT  - mTOR mammalian target of rapamycin
OT  - beta-Hydroxy-beta-methylbutyrate calcium
EDAT- 2016/02/27 06:00
MHDA- 2017/05/06 06:00
CRDT- 2016/02/27 06:00
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2017/05/06 06:00 [medline]
AID - S0007114516000465 [pii]
AID - 10.1017/S0007114516000465 [doi]
PST - ppublish
SO  - Br J Nutr. 2016 Apr;115(8):1360-9. doi: 10.1017/S0007114516000465. Epub 2016 Feb 
      26.