PMID- 26918360
OWN - NLM
STAT- MEDLINE
DCOM- 20170620
LR  - 20240210
IS  - 1421-9883 (Electronic)
IS  - 0253-4886 (Linking)
VI  - 33
IP  - 3
DP  - 2016
TI  - Management and Outcome of 64 Patients with Pancreatic Serous Cystic Neoplasms.
PG  - 203-12
LID - 10.1159/000442094 [doi]
AB  - BACKGROUND: The optimal management approach to pancreatic serous cystic neoplasms 
      (SCNs) is still evolving. METHODS: Consecutive patients with SCN managed at the 
      Liverpool Pancreas Cancer Centre between 2000 and 2013 were retrospectively 
      reviewed. RESULTS: There were 64 patients consisting of 39 women (60.9%) and 25 
      men (39.1%). Forty-seven patients (73.4%) had surgical removal and 17 (26.6%) 
      were observed. The possibility of a non-SCN malignancy was the predominant 
      indication for resection in 27 (57.4%) patients. Postoperative morbidity occurred 
      in 26 (55.3%) patients with 2 (4.3%) deaths. An increased risk of resection was 
      associated with patient's age (p = 0.011), diagnosis before 2009 (p < 0.001), 
      pain (p = 0.043), possibility of cancer (p = 0.009) and a solid SCN component on 
      imaging (p = 0.002). Independent factors associated with resection were a 
      diagnosis before 2009 (p = 0.005) and a solid SCN component (p < 0.001). 
      Independent factors associated with shorter time to surgical resection were 
      persistent pain (p = 0.003) and a solid SCN component (p = 0.007). CONCLUSION: 
      There was a reduction in the proportion of resections with the application of an 
      observe-only policy for asymptomatic patients with more definite features of SCN. 
      Improved criteria are still required in the remainder of patients with uncertain 
      features of SCN in deciding for intervention or surveillance.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Gomatos, Ilias P
AU  - Gomatos IP
AD  - National Institutes of Health Research Liverpool Pancreas Biomedical Research 
      Unit and Clinical Directorate of General Surgery, University of Liverpool, 
      Liverpool, UK.
FAU - Halloran, Christopher
AU  - Halloran C
FAU - Ghaneh, Paula
AU  - Ghaneh P
FAU - Raraty, Michael
AU  - Raraty M
FAU - Polydoros, Fotis
AU  - Polydoros F
FAU - Campbell, Fiona
AU  - Campbell F
FAU - Evans, Jonathan
AU  - Evans J
FAU - Sutton, Robert
AU  - Sutton R
FAU - Garry, Jo
AU  - Garry J
FAU - Whelan, Philip
AU  - Whelan P
FAU - Neoptolemos, John P
AU  - Neoptolemos JP
LA  - eng
GR  - 11883/CRUK_/Cancer Research UK/United Kingdom
GR  - 16186/CRUK_/Cancer Research UK/United Kingdom
GR  - 17680/CRUK_/Cancer Research UK/United Kingdom
GR  - 15957/CRUK_/Cancer Research UK/United Kingdom
GR  - 8968/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
DEP - 20160227
PL  - Switzerland
TA  - Dig Surg
JT  - Digestive surgery
JID - 8501808
SB  - IM
MH  - Abdominal Pain/etiology/surgery
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Endoscopic Ultrasound-Guided Fine Needle Aspiration
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Cystic, Mucinous, and Serous/diagnostic imaging/pathology/*therapy
MH  - *Pancreatectomy/adverse effects
MH  - Pancreatic Neoplasms/diagnostic imaging/pathology/*therapy
MH  - Pancreaticoduodenectomy/adverse effects
MH  - Postoperative Complications/etiology
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
MH  - *Watchful Waiting
EDAT- 2016/02/27 06:00
MHDA- 2019/03/21 06:00
CRDT- 2016/02/27 06:00
PHST- 2015/08/28 00:00 [received]
PHST- 2015/10/28 00:00 [accepted]
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
AID - 000442094 [pii]
AID - 10.1159/000442094 [doi]
PST - ppublish
SO  - Dig Surg. 2016;33(3):203-12. doi: 10.1159/000442094. Epub 2016 Feb 27.